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Development of Cancer Treatment System by Induction heating

感应加热癌症治疗系统的开发

基本信息

批准号：
17200034
负责人：
NAGANO Isamu
金额：
$ 28.04万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17200034/
关键词：
cancer treatment induction heating nano bio high frequency power source medical device heating for deep-seated cancer Embolism medical treatment TAE 癌磁気分離動物実験 DM ガン治療 VX-2

项目摘要

Essential elements of this project are as follows:1) Induction heating device2) Magnetic fluid t o be applicable for cancer patient3) Protocol for cancer treatment using magnetic fluidWe have researched about above mentioned elements.1. Development of induction heating device1-1 Development of applicator for deep seated cancerEddy current is a severe problem in case of human body. Because it might cause the burn. Therefore we have simulated it using the three dimension human body model.We have been able to realize the appropriate frequency and the suitable applicator type for deep seated cancer.1.2 Development of high performance deviceWe have improved the copper loss of applicator coil using "litz wire" and have improved the effectiveness of the electromagnetic wave using a ferrite. And we developed a new technology for resonance control system The power efficiency of the device increased to be as much as 2 times.2. Development of highly effective magnetic fluidMagnetic fluid, active … More ingredient of AIRI contrast agent "Resovist" is able to separate into seine fractions by various methods such as centrifugal separation, ultra-filtration, magnetic separation etc,. We have tried such separation and obtained highly effective magnetic fluid fraction(HEMF). Especially magnetic separation is effective to obtain IMF. Heat generation efficacy of the HEMF is 5.7 times in comparison with original magnetic fluid. In order to clarify the difference between the HEMF and original magnetic fluid, we have observed the shape of the ingredients nano-particles, under electron microscope. The particle size of original magnetic fluid is about 6nm. On the other hand the partide size of the ingredient of HEMF is more than 20 am that comprises with duster of small par-tides in diameter of 5〜6nm.3. Development of protocolAs mentioned above, we have obtained high efficient device. The effectiveness increased more than 10 times in comparison of former device. We made two devices and loaned to Faculty of Medicine Kanazawa University Fukui University Toyama University, the Osaka geriatric diseases center and the practicing animal hospital, etc. These devises were applied to various experimental cancer to develop useful protocols.We demonstrated induction heating hyperthermia using the device was effective for experimental lung cancer, breast cancer, lever cancer etc with favorable feasibility In summary we consider that this treatment system is a very beneficial and promising to cancer. Less

本项目的基本要素如下：1）感应加热装置2）适用于癌症患者的磁流体3）使用磁流体进行癌症治疗的方案我们对上述要素进行了研究。感应加热装置的研制1 -1深部癌肿治疗器的研制涡流对人体来说是一个严重的问题。因为它可能会导致烧伤。因此，我们使用三维人体模型进行了模拟。我们已经能够实现适当的频率和适用于深层癌症的施源器类型。1.2高性能设备的开发我们使用“利兹线”改善了施源器线圈的铜损耗，并使用铁氧体提高了电磁波的有效性。并开发了一种新的谐振控制技术，使装置的功率效率提高了2倍.高效磁流体的开发磁性流体，活性 ...更多信息 AIRI造影剂“Resovist”成分能够通过各种方法如离心分离、超滤、磁分离等分离成网状部分。我们已经尝试了这种分离，并获得了高效的磁流体馏分（HEMF）。特别是磁选是获得IMF的有效方法。HEMF的产热效率是原磁流体的5.7倍。为了阐明HEMF与原始磁流体的区别，我们在电子显微镜下观察了成分纳米颗粒的形状。原始磁流体的粒径约为6 nm。而HEMF组分的粒径在20 μ m以上，由直径为5 ~ 6 nm的小颗粒组成.通过以上工作，我们得到了高效的装置。与原装置相比，有效性提高了10倍以上。我们制作了两台设备并借给金泽大学医学部、福井大学、富山大学、大坂老年病中心和实践动物医院等。这些设备被应用于各种实验性癌症，以开发有用的方案。我们证明使用该设备的感应加热热疗对实验性肺癌、乳腺癌、总之，我们认为这种治疗系统对癌症是非常有益和有前途的。少