Development of Cancer Treatment System by Induction heating

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Essential elements of this project are as follows:1) Induction heating device2) Magnetic fluid t o be applicable for cancer patient3) Protocol for cancer treatment using magnetic fluidWe have researched about above mentioned elements.1. Development of induction heating device1-1 Development of applicator for deep seated cancerEddy current is a severe problem in case of human body. Because it might cause the burn. Therefore we have simulated it using the three dimension human body model.We have been able to realize the appropriate frequency and the suitable applicator type for deep seated cancer.1.2 Development of high performance deviceWe have improved the copper loss of applicator coil using "litz wire" and have improved the effectiveness of the electromagnetic wave using a ferrite. And we developed a new technology for resonance control system The power efficiency of the device increased to be as much as 2 times.2. Development of highly effective magnetic fluidMagnetic fluid, active … More ingredient of AIRI contrast agent "Resovist" is able to separate into seine fractions by various methods such as centrifugal separation, ultra-filtration, magnetic separation etc,. We have tried such separation and obtained highly effective magnetic fluid fraction(HEMF). Especially magnetic separation is effective to obtain IMF. Heat generation efficacy of the HEMF is 5.7 times in comparison with original magnetic fluid. In order to clarify the difference between the HEMF and original magnetic fluid, we have observed the shape of the ingredients nano-particles, under electron microscope. The particle size of original magnetic fluid is about 6nm. On the other hand the partide size of the ingredient of HEMF is more than 20 am that comprises with duster of small par-tides in diameter of 5〜6nm.3. Development of protocolAs mentioned above, we have obtained high efficient device. The effectiveness increased more than 10 times in comparison of former device. We made two devices and loaned to Faculty of Medicine Kanazawa University Fukui University Toyama University, the Osaka geriatric diseases center and the practicing animal hospital, etc. These devises were applied to various experimental cancer to develop useful protocols.We demonstrated induction heating hyperthermia using the device was effective for experimental lung cancer, breast cancer, lever cancer etc with favorable feasibility In summary we consider that this treatment system is a very beneficial and promising to cancer. Less