Clarification of cell polarity formation mechanism in archenteron formation

2007财年对肠原体形成过程中细胞迁移的控制和细胞极性形成的研究取得了显著的成果。研究代表Ueno认为细胞粘附的正向限制因子ANR5是细胞迁移的负向控制机制。ANR5是被鉴定为细胞生长因子FGF ANR5靶基因的基因之一，并明确了通过与PAPC直接结合来精确控制细胞粘附，通过过度外观和使用[moruforinoanchisensuorigonukureochido]的功能抑制来控制下游RhoA的再生。此外，ANR5对于形成一个薄膜投影是必要的，这样细胞就可以在群体中相互移动，因此，它被澄清在肠原子形成中起着不可或缺的作用(Chung， H. a .等，Curr。杂志)。此外，Kinoshita等人阐明了肠原体形成的细胞运动是通过细胞生长因子Wnt作用于中成细胞，并控制[pakishirin]的泛素相关分辨率来调节的，在细胞运动中起着不可或缺的作用（Iioka， H.等，Nat cell Biol.）。这些重要的研究结果表明，作为细胞群的运动对于肠原体的形成是不可或缺的。此外，Ueno澄清了关于原始肠形成时所见细胞的形态和功能极性形成的起始机制关注微管延伸的分析，并且段落之间生成过程的边界具有极性开始信号（Shindo, a .等，PLoS ONE）。我想在未来推进对这一极性起始信号实质的研究。

Remarkable study results were obtained for the control and the cell polarity formation of the cell migration in the archenteron formation in 2007 fiscal year. Research representative's Ueno identified positive restrictor ANR5 of the cellular adhesion as a negative controlling mechanism of the cell migration. ANR5 was one of the genes identified as a target gene of cellular growth factor FGF ANR5, and clarified that the cellular adhesion was exactly controlled by uniting directly with PAPC and controlling the RhoA revitalization in the downstream by excessive appearance and the functional inhibition that used [moruforinoanchisensuorigonukureochido]. Moreover, ANR5 was necessary for forming a film projection necessary so that the cell may move mutually in the group, and, as a result, it was clarified to play an indispensable role to the archenteron formation (Chung, H. A., et. al., Curr. Biol.). Moreover, Kinoshita, et al. clarified that the cell movement of the archenteron formation was adjusted by cellular growth factor's Wnt acting on the mesoblast cell, and controlling the ubiquitin related resolution of [pakishirin] with an indispensable role to the cell movement (Iioka, H., et. al., Nat Cell Biol.). These are important study results in which it is shown that the movement as the group of the cell is indispensable to the archenteron formation. In addition, Ueno clarified that the analysis that paid attention to the microtubule elongation about the initiation mechanism of a form and functional polarity making about the cell seen when the primitive gut was formed was done, and the boundary of the generation process between paragraphs had the polarity beginning signal (Shindo, A., et. al. PLoS ONE). I want to advance the research on the substance of this polarity beginning signal in the future.