Significance of membrane/protein trafficking for the establishment of cell polarity in the vertebrate

膜/蛋白质运输对于脊椎动物细胞极性建立的意义

• 批准号: 21370102
• 负责人: UENO Naoto
• 金额: $ 12.15万
• 依托单位: National Institute for Basic Biology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21370102/
• 关键词: 細胞極性; タンパク質輸送; 細胞骨格; 原腸形成; 初期発生

We have demonstrated that for the establishment of cell polarity, stabilization and bundling of microtubule are essential and that molecules implicated in epithelial morphogenesis such as MID1 encoded by a causative gene of Opitz syndrome and its related protein MID2 play important role in the stabilization/bundling of microtubules. Thus we have been able to propose that this remodeling of microtubules allows the trafficking of secreted vesicles and cell polarity factors on the rail of bundled microtubules.

我们已经证明，对于细胞极性的建立，微管的稳定和捆绑是必不可少的，与上皮形态发生有关的分子，如Opitz综合征的致病基因编码的MID1及其相关蛋白MID2，在微管的稳定/捆绑中发挥着重要作用。因此，我们已经能够提出，这种微管的重塑允许分泌的囊泡和细胞极性因子在捆绑的微管轨道上运输。

项目成果

Dissecting the contribution of non-neural ectoderm to the verte-brate neural tube closure

剖析非神经外胚层对脊椎动物神经管闭合的贡献

• 发表时间: 2011
• 作者: Herpin;A.;Braasch;I.;Kraeusslling;M.;Schmidt;C.;Thoma;E. C.;Nakamura;S.;Tanaka;M. and Schartl;M;森田仁
• 通讯作者: 森田仁

Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.

• DOI: 10.1016/j.ydbio.2012.01.025
• 发表时间: 2012-04-15
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: Tao H;Inoue K;Kiyonari H;Bassuk AG;Axelrod JD;Sasaki H;Aizawa S;Ueno N
• 通讯作者: Ueno N

Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis

• DOI: 10.1242/dev.043190
• 发表时间: 2010-04-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Morita, Hitoshi;Nandadasa, Sumeda;Ueno, Naoto
• 通讯作者: Ueno, Naoto

ゼブラフィッシュ神経管形成における非筋型ミオシンの時空間分布

斑马鱼神经管形成过程中非肌肉肌球蛋白的时空分布

• 发表时间: 2011
• 作者: Ishikawa;H. O.;Ayukawa;T.;Nakayama;N.;Higashi;S.;Kamiyama;S.;Nishihara;S.;Aoki;K.;Ishida;N.;Sanai;Y.;and Matsuno;K;鈴木誠
• 通讯作者: 鈴木誠

Regulation for Xenopus neural tube morphogenesis by nectin-2, an Ig-like adhesion molecule in cooperation with N-cadherin

nectin-2（一种 Ig 样粘附分子与 N-钙粘蛋白的配合）对非洲爪蟾神经管形态发生的调节

• 发表时间: 2009
• 作者: Ding;D.-Q.;森田仁
• 通讯作者: 森田仁