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Significance of membrane/protein trafficking for the establishment of cell polarity in the vertebrate

Significance of membrane/protein trafficking for the establishment of cell polarity in the vertebrate
膜/蛋白质运输对于脊椎动物细胞极性建立的意义
批准号:
21370102
负责人:
UENO Naoto
金额:
$12.15万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
翻译
我们已经证明,对于细胞极性的建立,微管的稳定和捆绑是必不可少的,并且涉及上皮形态发生的分子,如由Opitz综合征致病基因编码的MID1及其相关蛋白MID2在微管的稳定/捆绑中发挥重要作用。因此,我们已经能够提出这种微管的重塑允许在捆绑微管的轨道上运输分泌囊泡和细胞极性因子。
英文摘要
We have demonstrated that for the establishment of cell polarity, stabilization and bundling of microtubule are essential and that molecules implicated in epithelial morphogenesis such as MID1 encoded by a causative gene of Opitz syndrome and its related protein MID2 play important role in the stabilization/bundling of microtubules. Thus we have been able to propose that this remodeling of microtubules allows the trafficking of secreted vesicles and cell polarity factors on the rail of bundled microtubules.
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会议论文
Dissecting the contribution of non-neural ectoderm to the verte-brate neural tube closure
剖析非神经外胚层对脊椎动物神经管闭合的贡献
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Herpin, A., Braasch, I., Kraeusslling, M., Schmidt, C., Thoma, E. C., Nakamura, S., Tanaka, M. and Schartl, M, 森田仁]
通讯作者: 森田仁
DOI: 10.1016/j.ydbio.2012.01.025
发表时间: 2012-04-15
期刊: Developmental biology
影响因子: 2.7
作者: [Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa S, Ueno N]
通讯作者: Ueno N
DOI: 10.1242/dev.043190
发表时间: 2010-04-15
期刊: DEVELOPMENT
影响因子: 4.6
作者: [Morita, Hitoshi, Nandadasa, Sumeda, Ueno, Naoto]
通讯作者: Ueno, Naoto
ゼブラフィッシュ神経管形成における非筋型ミオシンの時空間分布
斑马鱼神经管形成过程中非肌肉肌球蛋白的时空分布
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ishikawa, H. O., Ayukawa, T., Nakayama, N., Higashi, S., Kamiyama, S., Nishihara, S., Aoki, K., Ishida, N., Sanai, Y., and Matsuno, K, 鈴木誠]
通讯作者: 鈴木誠
9
    Development of methodologies to study Aiptasia-Symbiodinium symbiosis
    • 批准号:
      25650087
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.66万
    • 财政年份:
      2013
    • 负责人:
      UENO Naoto
    • 依托单位:
    Identification of the biological significance of small chemicals for morphogenesis
    • 批准号:
      24370092
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.73万
    • 财政年份:
      2012
    • 负责人:
      UENO Naoto
    • 依托单位:
    Clarification of cell polarity formation mechanism in archenteron formation
    • 批准号:
      17207015
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.28万
    • 财政年份:
      2005
    • 负责人:
      UENO Naoto
    • 依托单位:
    Dynamics of Developmental Systems
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