Epidemiological studies of the relationships between periodontal diseases and systemic health

牙周病与全身健康关系的流行病学研究

• 批准号: 17209066
• 负责人: WATANABE Tatsuo
• 金额: $ 31.78万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17209066/
• 关键词: Periodontal disease; Periodontal medicine; Biochemical test; Diabetes; Stress; Hepatic steatosis; Aspiration pneumonia; Hypercholesterolemia

The purpose of this research project was to examine the casual and epidemiological relationships between periodontal diseases and systemic health. We obtained conclusions described below from seven different experimental groups.1.(Miyazaki H) We analyzed the relationship between periodontal disease progression and serum vitamin C, calcium and albumin concentrations obtained from community-dwelling elderly Japanese aged 78 years. The results suggest that lower vitamin C, calcium and albumin levels independently influence to progress periodontal destruction in elderly people.2.(Takehara T and Ansai T) We analyzed an association between the rate of eating and adipocyte-derived hormones, adiponectin and leptin. It was suggested that chewing well and eating slow may lead to a preventive strategy for metabolic syndrome.3.(Nakagaki H) This study was undertaken the relation between smoking habits and blood test values of persons with periodontitis. The results of this study helped clarify the … More relationship between the CRP value and periodontal disease, suggesting the possibility that this can be used as a screening test for periodontal disease.4.(Yamashita Y and Saito T) Periodontal disease was closely associated with metabolic syndrome in Japanese women. Within several kinds of adipocytokines, resistin was suggested to be elevated in the subjects with periodontal disease.5.(Nishimura F) Infection by P. gingivalis was associated with elevated LDL-cholesterol. This appeared to be accompanied by increased cholesterol synthesis, which was induced by up-regulation of HMG-CoA mRNA level by TNF-a and IL-6 produced by periodontal infection.6.(Watanabe T, Yamamoto T and Tomofuji T) We established experimental rat periodontitis model by topical application of lipopolysaccharide and proteases. In rat periodontitis model, oxidative damage of brain, heart, liver and kidney were found.7.(Shizukuishi S) FomA, F. nucleatum outer membrane protein (OMP) bound to salivary statherin-peptide and induced mucosal and systemic immune responses in mice given with cholera toxin as mucosal adjuvant. Less

本研究旨在探讨牙周病与全身健康之间的因果关系和流行病学关系。我们从七个不同的实验组中获得了以下结论。（宫崎H）我们分析了牙周病进展与血清维生素C、钙和白蛋白浓度之间的关系，这些数据来自78岁的日本社区老年人。结果提示，维生素C、钙和白蛋白水平的降低独立影响老年人牙周组织破坏的进展.（竹原T和安塞T）我们分析了进食率与脂肪细胞源性激素脂联素和瘦素之间的关系。研究表明，细嚼慢咽可能是代谢综合征的预防策略。（Nakagaki H）本研究对牙周炎患者的吸烟习惯与血液检查值之间的关系进行了研究。这项研究的结果有助于澄清 ...更多信息 CRP值与牙周病之间的关系，提示其可作为牙周病的筛查试验.（Yamashita Y和Saito T）日本女性的牙周病与代谢综合征密切相关。在几种脂肪细胞因子中，牙周病患者血清中β-淀粉样蛋白水平升高.（Nishimura F）牙龈卟啉单胞菌感染与LDL-胆固醇升高相关。这似乎伴随着胆固醇合成增加，这是由牙周感染产生的TNF-α和IL-6上调HMG-CoA mRNA水平诱导的。（Watanabe T，Yamamoto T和Tomofuji T）我们通过局部应用脂多糖和蛋白酶建立实验性大鼠牙周炎模型。大鼠牙周炎模型中，脑、心、肝、肾均存在氧化损伤.（Shizukuishi S）FomA，F.核外膜蛋白（OMP）结合唾液statherin肽，并诱导粘膜和全身免疫反应的小鼠给予霍乱毒素作为粘膜佐剂。少

项目成果

Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.

• DOI: 10.1111/j.1741-2358.2005.00059.x
• 发表时间: 2005-06-01
• 期刊: Gerodontology
• 影响因子: 2
• 作者: Akifusa, S;Soh, I;Takehara, T
• 通讯作者: Takehara, T

Associations between salivary chromogranin A and xerostomia in elderly subjects : a pilot study

老年受试者唾液嗜铬粒蛋白 A 与口干症之间的关联：一项试点研究

• 发表时间: 2006
• 期刊: Int J Oral Health 3
• 作者: 恵比須繁之;ら;Horikawa M et al.
• 通讯作者: Horikawa M et al.

Can presence of carotid artery calcification on panoramic radiographs predict vascular-related risks among old subjects?

全景X光片上颈动脉钙化的存在能否预测老年受试者的血管相关风险？

• 发表时间: 2006
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101
• 作者: Ebisu;S;et. al.;Tanaka T et al.
• 通讯作者: Tanaka T et al.

Tooth loss associated with abnormal electrocardiographic findings in octogenarians

八旬老人的牙齿脱落与心电图异常相关

• 发表时间: 2005
• 期刊: Journal of Kyushu Dental Society 59
• 作者: Takata;Y. et al.
• 通讯作者: Y. et al.

Hyperglycemia promote microinflammation as evaluated by C-reactive protein in the very elderly

根据 C 反应蛋白评估，高血糖会促进老年人的微炎症

• 期刊: Intern Med (in press)
• 作者: Ebisu;S;et. al.;Fukuhara M et al.;Kataoka K et al.;Sonoki K et al.;Takata Y et al.;Takata Y et al.;Yamashita A et al.;Yoshizawa S et al.;Fukuhara M et al.
• 通讯作者: Fukuhara M et al.