Chemical biology targeting the brain : Molecular design of anticancer agents that efficiently attack brain tumors

肿瘤化疗对脑肿瘤的疗效很大程度上受到细胞机制的限制，因为血脑屏障限制了药物进入大脑。atp结合盒（ABC）转运体，如ABCB1和ABCG2，起着关键作用。在本研究项目中，我们开发了高速筛选和定量构效关系（QSAR）分析方法，以设计有效靶向脑肿瘤的抗癌药物分子。

The efficacy of cancer chemotherapy in brain tumors is substantially limited by cellular mechanisms where the blood-bran-barrier limits drug penetration into the brain. ATP-binding cassette (ABC) transporters, e.g., ABCB1 and ABCG2, play pivotal roles. In this research project, we have developed high-speed screening and quantitative structure-activity-relationship (QSAR) analysis methods to design anticancer drug molecules that efficiently target brain tumors.