Anisotropic dynamics of ice growth promotion and its self-oscillation induced by the interfacial adsorption of biological macro molecules

生物大分子界面吸附引起的冰生长促进各向异性动力学及其自振荡

• 批准号: 18204036
• 负责人: FURUKAWA Yoshinori
• 金额: $ 30.37万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18204036/
• 关键词: 生物物理; 凍結抑制タンパク質; 氷結晶; 結晶成長; 界面吸着; 自励振動; 協同現象; 生体高分子; 不凍タンパク質; 吸着; 結晶成長カイネティクス; 界面吸着現象; タンパク質分画; 自励振動成長; FTIR; 二次構造

Experimental and theoretical studies of antifreeze proteins, which have the special function to prevent the freezing of living organisms under the subzero environment, were carried out. Direct evidence for the relation between the adsorption of proteins on the ice interfaces and the prohibition of crystal growth was first demonstrated directly, and it was made clear that the protein molecule adsorption proceeded in two stages depending on the conformation change of protein molecules. This adsorption mode was completely new and called as "two-step reversible adsorption". This adsorption model also explained the growth promotion of basal planes of ice and the self oscillations of growth rates.

抗冻蛋白是一种在低温环境下对生物体具有特殊抗冻功能的蛋白质，本文对其进行了实验和理论研究。首次直接论证了蛋白质在冰界面上的吸附与晶体生长受阻之间的关系，明确了蛋白质分子的吸附根据蛋白质分子构象的变化分两个阶段进行。这是一种全新的吸附模式，被称为“两步可逆吸附”。该吸附模型还解释了冰基面的生长促进和生长速率的自振荡现象。

项目成果

不凍タンパク質が氷の結晶成長を支配する-界面現象してのメカニズム-(招待講演)

抗冻蛋白控制冰晶生长 - 作为界面现象的机制 - （特邀演讲）

• 发表时间: 2009
• 作者: D. Konstantinov;Yu. P. Monarkha;and K. Kono;古川義純
• 通讯作者: 古川義純

Antifreeze proteins-How do they effect ice crystal growth? (Invited)

抗冻蛋白——它们如何影响冰晶生长？

• 发表时间: 2008
• 作者: 山本 潤・西山伊佐;尾中敬;Yoshinori Furukawa
• 通讯作者: Yoshinori Furukawa

Reversible adsorption of antifreeze glycoproteins and ice growth

抗冻糖蛋白的可逆吸附和冰生长

• 发表时间: 2008
• 作者: 原秀明;榎本勝成;北川昌明;高須洋介;高橋義朗;Yoshinori Furukawa;Yoshinori Furukawa;Y. Takahashi;Yoshinori Furukawa;Y. Takahashi;Y. Takahashi;Y. Furukawa
• 通讯作者: Y. Furukawa

Antifreeze(glycol)proteins-How do they affect ice crystal growth?(Invited)

抗冻（乙二醇）蛋白——它们如何影响冰晶生长？（特邀）

• 发表时间: 2009
• 作者: Ulrich Welp;Alexei Koshelev;Lutfi Ozyuzer;Cihan Kurter;Masashi Tachiki;Kazuo Kadowaki;Takashi Yamamoto and Wai -K. Kwok;田辺俊彦;Yoshinori Furukawa
• 通讯作者: Yoshinori Furukawa

Growth of ice disk: Dependence of critical thickness for ice disk instability on supercooling of water.

冰盘的增长：冰盘不稳定的临界厚度对水过冷的依赖性。

• 发表时间: 2009
• 期刊: Journal of Physical Chemistry B113
• 作者: E. Yokoyama;R.F. Sekerka;Y. Furukawa
• 通讯作者: Y. Furukawa