Development of safe liver transplantation by modulation of transcription factor, nuclear factor kappa B (NF-kB)

通过调节转录因子、核因子 kappa B (NF-kB) 开发安全肝移植

• 批准号: 18209041
• 负责人: 藤堂 省
• 金额: $ 31.7万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18209041/
• 关键词: NF-kB; 免疫抑制; 臓器保存; 虚血再灌流障害; 臓器移植; 肝移植; 拒絶反応; NF kappa B; 虚血再灌流; NF-KB; DHMEQ; 虚血・再かん流障害

移植後の拒絶反応と炎症を軽減するために、新規NF-kB阻害剤Qの効果、投与法、剤型を検討した。拒絶、炎症に関わる免疫担当細胞の抑制や、小動物の肝、小腸、心、膵島細胞移植および虚血再灌流で有効性が確認された。また、新規臓器保存液を試作し、肝および多くの細胞や心移植における冷保存障害の軽減に成功した。臨床開発に不可欠な生体~細胞での有効性が確認され、新たな臓器保護法の実用化が期待される。

After transplantation, the rejection of anti-inflammatory drugs, new NF-kB inhibitor Q effect, injection method and type of drugs are discussed. Rejection, inflammation related immune cells inhibition, small animal liver, small intestine, heart, small island cell transplantation and hypoperfusion have been confirmed. In addition, the new preservation solution was successfully used to reduce the cold preservation damage of liver and heart transplantation. Clinical development requires confirmation of the effectiveness of biological and cellular systems, and the implementation of new organ protection methods is expected.

项目成果

Effect of NF-kB Inhibition by DHMEQ on islet transplantation in mice

DHMEQ抑制NF-kB对小鼠胰岛移植的影响

• 发表时间: 2008
• 作者: Tomomi Suzuki;Kenichiro Yamashita;Wataru Jomen;Shinya Ueki;Takeshi Aoyagi;Moto Fukai;Hiroyuki Furukawa;Kazuo Umezawa;Michitaka Ozaki;Satoru Todo;MotoFukai;Ryoichi Goto;Tetsu Oura;Masaaki Watanabe;Takeshi Aoyagi;Tomomi Suzuki;Yuka Oshima;Ryoichi Goto;Motohiro Uno;Tetsu Oura;Motohiro Uno;Masaaki Watanabe
• 通讯作者: Masaaki Watanabe

A novel human anti-CD40 monoclonal antibody, 4D11, for liver transplantation in non-human primate

一种新型人抗 CD40 单克隆抗体 4D11，用于非人灵长类动物肝移植

• 发表时间: 2008
• 作者: Mori T;Kabashima K;Yoshiki R;Sugita K;Shiraishi N;Kuroda E;Yamashita U;Tokura Y.;菅原裕子;Tetsu Oura
• 通讯作者: Tetsu Oura

Regulation of Splan-chnic Circulation in Adult to Adult liviDonorLiverTransplantation

成人供体肝移植中内脏循环的调节

• 发表时间: 2008
• 作者: Saito S;Nakatani T;Kobayashi J;Tagusari O;Bando K;Niwaya K;Nakajima H;Miyazaki S;Yagihara T;Kitamura S;Masahiko Taniguchi
• 通讯作者: Masahiko Taniguchi

Impact of induction with Basiliximab in combination with Tacrolimus-based immunosuppressive regimenin living donor livetransplantation

巴利昔单抗诱导联合基于他克莫司的免疫抑制方案对活体供体活体移植的影响

• 发表时间: 2008
• 作者: Zhang D;Kaneda M;Nakahama KI;Arii S;Morita I.;Takeshi Aoyagi
• 通讯作者: Takeshi Aoyagi

A novel NF-kappa Binhibitor, DHMEQ, attenuates arteria vasculopathy. American

一种新型 NF-kappa 抑制剂 DHMEQ 可减轻动脉血管病变。

• 发表时间: 2008
• 作者: Tanaka H;et. al.;Motohiro Uno
• 通讯作者: Motohiro Uno