Research of the Molecular Network Regulating Endochondral Ossification

软骨内骨化调控分子网络的研究

• 批准号: 18209047
• 负责人: KAWAGUCHI Hiroshi
• 金额: $ 31.45万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18209047/
• 关键词: 骨; 軟骨代謝学; 軟骨代謝; 転写因子; p63; 軟骨細胞; 軟骨内骨化; 軟骨

We identified a transcription factor p63 as the potent inducer of SOX6, a member of SOX family essential for chondrocyte generation and differentiation. In this study, we revealed that p63 was extensively expressed in chondrocytes, that p63 was indispensable for development of limb cartilage, and that p63 played important roles in every differentiation stages of chondrocytes.

我们确定转录因子 p63 是 SOX6 的有效诱导剂，SOX6 是 SOX 家族的成员，对于软骨细胞的生成和分化至关重要。在本研究中，我们揭示了p63在软骨细胞中广泛表达，p63对于肢体软骨的发育是不可缺少的，并且p63在软骨细胞的各个分化阶段都发挥着重要作用。

项目成果

Molecular backgrounds of age-related osteoporosis from mouse genetics approaches

• DOI: 10.1007/s11154-006-9011-3
• 发表时间: 2006-06-01
• 期刊: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
• 影响因子: 8.2
• 作者: Kawaguchi, Hiroshi

Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly : Dietary survey in a population-based cohort of the ROAD study.

膳食维生素 K 摄入量低与日本老年人的放射学膝骨关节炎相关：ROAD 研究中基于人群的膳食调查。

• 发表时间: 2009
• 期刊: J Orthop Sci 14
• 作者: Hiroyuki Oka;Hiroshi Kawaguchi;et al
• 通讯作者: et al

Aktl in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions

小鼠软骨细胞中的 Aktl 在生理和病理条件下控制软骨内骨化过程中的软骨钙化

• 发表时间: 2010
• 期刊: Arthritis Rheum 62(3)
• 作者: Fukai A;Kawamura N;Saito T;Oshima Y;Ikeda T;Kugimiya F;Higashikawa A;Yano F;Ogata N;Nakamura K;Chung UI;Kawaguchi H.
• 通讯作者: Kawaguchi H.

C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2.

C/EBPβ 通过 p57Kip2 的反式激活促进软骨细胞从增殖向肥大分化的转变。

• 发表时间: 2009
• 期刊: PLoS ONE(in press)
• 作者: Tomoo Oda;et. al.;Ogasawara T et al.;Asawa Y et al.;Hirata M et al.
• 通讯作者: Hirata M et al.

Identification of the Core Element Responsive to Runt-Related Transcription Factor 2 in the Promoter of Human Type X Collagen Gene

• DOI: 10.1002/art.24243
• 发表时间: 2009-01-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Higashikawa, Akiro;Saito, Taku;Kawaguchi, Hiroshi
• 通讯作者: Kawaguchi, Hiroshi