Stud aiming at elucidating the molecular mechanism behind spondylosis through establishing cre / lox P system in the field of intervertebral disc.

旨在通过建立椎间盘领域的cre/lox P系统来阐明脊椎病背后的分子机制。

• 批准号: 23659706
• 负责人: KAWAGUCHI Hiroshi
• 金额: $ 2.25万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659706/
• 关键词: 脊椎脊髄病学; 椎間板; 変形性脊椎症; 椎間板変性

We established a new mouse model of spondylosis. In this model, we identified that annulus fibrosus cells exhibit hypertrophic change morphologically with expression of type 10 collagen. Also we succeeded in identifying a candidate gene which can be a marker of annulus fibrosus of intervertebral disc.

我们建立了一种新的颈椎病小鼠模型。在这个模型中，我们发现纤维环细胞在形态上表现出肥大的变化，并表达10型胶原。我们还成功地鉴定了一个可能作为椎间盘纤维环标志物的候选基因。

项目成果

Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study

• DOI: 10.1016/j.joca.2012.06.018
• 发表时间: 2012-10-01
• 期刊: OSTEOARTHRITIS AND CARTILAGE
• 影响因子: 7
• 作者: Ishimoto, Y.;Yoshimura, N.;Yoshida, M.
• 通讯作者: Yoshida, M.

C/EBPss and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

软骨细胞中C/EBPss与RUNX2协同降解软骨，以MMP-13为靶点，以HIF-2α为诱导剂

• 发表时间: 2012
• 期刊: Hum Mol Genet
• 影响因子: 3.5
• 作者: Hirata M;Kugimiya F;Fukai A;Saito T;Yano F;Ikeda T;Mabuchi A;Sapkota BR;Akune T;Nishida N;Yoshimura N;Nakagawa T;Tokunaga K;Nakamura K;Chung UI;Kawaguchi H
• 通讯作者: Kawaguchi H

Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice

• DOI: 10.1002/art.33324
• 发表时间: 2012-01-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Fukai, Atsushi;Kamekura, Satoru;Kawaguchi, Hiroshi
• 通讯作者: Kawaguchi, Hiroshi

GSK-3α and GSK-3ss proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation

GSK-3α 和 GSK-3ss 蛋白参与软骨细胞分化的早期阶段，通过 RelA 蛋白磷酸化实现功能冗余

• 发表时间: 2012
• 期刊: J Biol Chem
• 影响因子: 4.8
• 作者: Itoh S;Saito T;Hirata M;Ushita M;Ikeda T;Woodgett JR;Algul H;Schmid RM;Chung UI;Kawaguchi H
• 通讯作者: Kawaguchi H

ss-catenin regulates parathyroidhormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor

ss-catenin 通过与受体的细胞内 C 末端区域结合来调节甲状旁腺激素/甲状旁腺激素相关蛋白受体信号和软骨细胞肥大

• 发表时间: 2013
• 期刊: Arthritis Rheum
• 作者: Yano F;Saito T;Ogata N;Yamazawa T,Iino M;Chung UI;Kawaguchi H
• 通讯作者: Kawaguchi H