Stud aiming at elucidating the molecular mechanism behind spondylosis through establishing cre / lox P system in the field of intervertebral disc.
Stud aiming at elucidating the molecular mechanism behind spondylosis through establishing cre / lox P system in the field of intervertebral disc.
批准号:
23659706
负责人:
KAWAGUCHI Hiroshi
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
We established a new mouse model of spondylosis. In this model, we identified that annulus fibrosus cells exhibit hypertrophic change morphologically with expression of type 10 collagen. Also we succeeded in identifying a candidate gene which can be a marker of annulus fibrosus of intervertebral disc.
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DOI:
10.1016/j.joca.2012.06.018
发表时间:
2012-10-01
期刊:
OSTEOARTHRITIS AND CARTILAGE
影响因子:
7
作者:
[Ishimoto, Y., Yoshimura, N., Yoshida, M.]
通讯作者:
Yoshida, M.
C/EBPss and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
软骨细胞中C/EBPss与RUNX2协同降解软骨,以MMP-13为靶点,以HIF-2α为诱导剂
DOI:
--
发表时间:
2012
期刊:
Hum Mol Genet
影响因子:
3.5
作者:
[Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, Kawaguchi H]
通讯作者:
Kawaguchi H
DOI:
10.1002/art.33324
发表时间:
2012-01-01
期刊:
ARTHRITIS AND RHEUMATISM
影响因子:
--
作者:
[Fukai, Atsushi, Kamekura, Satoru, Kawaguchi, Hiroshi]
通讯作者:
Kawaguchi, Hiroshi
GSK-3α and GSK-3ss proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation
GSK-3α 和 GSK-3ss 蛋白参与软骨细胞分化的早期阶段,通过 RelA 蛋白磷酸化实现功能冗余
DOI:
--
发表时间:
2012
期刊:
J Biol Chem
影响因子:
4.8
作者:
[Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algul H, Schmid RM, Chung UI, Kawaguchi H]
通讯作者:
Kawaguchi H
ss-catenin regulates parathyroidhormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor
ss-catenin 通过与受体的细胞内 C 末端区域结合来调节甲状旁腺激素/甲状旁腺激素相关蛋白受体信号和软骨细胞肥大
DOI:
--
发表时间:
2013
期刊:
Arthritis Rheum
影响因子:
--
作者:
[Yano F, Saito T, Ogata N, Yamazawa T,Iino M, Chung UI, Kawaguchi H]
通讯作者:
Kawaguchi H
共 6 条
Deep Learning Processor for Pipelined Backpropagation
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批准号:18H01500
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.82万
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财政年份:2018
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Autophagy mechanism in cartilage chonsrocytes.
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批准号:25670629
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2013
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Japanese Economic Thought : Time and Space
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批准号:25380256
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2013
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Relation between optical intrinsic signal imaging on regulation of microcirculation on mice somatosensory cortex
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批准号:22700441
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.91万
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财政年份:2010
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Strategic research for elucidation of molecular pathophysiology and identification of therapeutic target of lumbar spondylosis
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批准号:22249056
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.45万
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财政年份:2010
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Construction of a Historical GIS for Analyzing the Population Distribution in Pre-Modern Japan
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批准号:21300098
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.07万
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财政年份:2009
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Super-Low-Operating-Voltage Dependable SRAM Using Total Variability Suppression Effects in FD-SOI
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批准号:20360161
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
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财政年份:2008
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Data analysis system for historical demography and genealogy in pre-modern Japan
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批准号:18500198
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2006
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Research of the Molecular Network Regulating Endochondral Ossification
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批准号:18209047
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.45万
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财政年份:2006
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Elucidation of molecular mechanism involved in mechanical stress signaling in bone - functional analysis, contribution to pathology, and cloning of related molecule of a novel gene Znt5 -
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批准号:15390451
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2003
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Mechanism of regulation of bone and cartilage metabolism by fibroblast growth factor-18 (FGF-18)
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批准号:12470303
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2000
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Stimulatory effects of fibroblast growth facor-2 on bone formation and bone resorption
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批准号:09307033
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$15.94万
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财政年份:1997
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Stereochemistny and Reactivity of the Complexes with Co-C bond Obtained by Photodecarboxylation
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批准号:08454211
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.9万
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财政年份:1996
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Study on Mass Spectrometry for Nonmetallic Elements with Reduced-Pressure ICP
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批准号:08455387
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.69万
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财政年份:1996
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Radio-Frequency Glow-Discharge Mass Spectrometry for Direct Analysis of Sintered Ceramics
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批准号:04650677
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1992
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Mechanism of Coordination-site Exchange Reaction of the Cobalt(III) Complexes Containing Multidentate Ligands
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批准号:02640481
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1990
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负责人:KAWAGUCHI Hiroshi
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依托单位:
Mechanism of Interference Effects by Matrix Element and Elimination of the Effect in ICP Mass Spectrometry
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批准号:01550573
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.15万
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财政年份:1989
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负责人:KAWAGUCHI Hiroshi
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依托单位:
海外基金