Measurement and control of cellular functions using spatio-temporal electrical stimulation

研究了时空电刺激对细胞活性的影响。连续施加2hz刺激12小时，培养的心肌细胞收缩节律大致相同。在培养的皮层神经元中，时空刺激的历史反映在它们的诱发反应中。研制了一种用于干细胞胚状体整体刺激的微腔阵列装置。细胞内钙瞬变是由刺激引起的，有望作为调节细胞分化的工具。

Modification of cellular activity induced by spatio-temporal electrical stimulation was studied. Continuous application of2Hz stimulus for12hours elicited approximately the same contraction rhythm in cultured cardiomyocytes. In cultured cortical neurons, the history of spatio-temporal stimulation was reflected in their evoked responses. A novel microcavity-array device was developed for ensemble stimulation of embryoid bodies of stem cells. Intracellular calcium transients were elicited by the stimulus, which would be promising as a tool for regulating cell differentiation.