The role of mechanosensor on cardiovascular disease.

为了阐明体内力学转导系统，有必要进行针对力学敏感通道分子的分子细胞生理学分析，以及使用敲除小鼠的生理学评估。在这项研究中，我们将检查是否血流动力学负荷，如高血压，可以导致这种功能障碍的机械敏感通道，并探讨的作用，机械传感器有关的肥厚的形成和进展的心力衰竭。阐明参与心力衰竭加重的分子途径将使我们能够筛选符合实际临床环境的新治疗靶分子和治疗研究对象。

In order to elucidate the in vivo mechanotransduction system, it is essential to conduct molecular cell physiological analysis targeting mechanosensitive channel molecules, as well as physiological assessment using knockout mice. In this study, we will examine whether or not hemodynamic loads such as hypertension can cause such dysfunction of the mechanosensitive channel, and explore the roles of the mechanosensor in relation to the formation of hypertrophy and progression of heart failure. The elucidation of the molecular pathway involved in the exacerbation of heart failure will enable us to sift through novel treatment target molecules and treatment research subjects in line with the actual clinical settings.