The role of mechanosensor on cardiovascular disease.

为了阐明体内的机械转导系统，有必要针对机械敏感通道分子进行分子细胞生理分析，并利用敲除小鼠进行生理评估。在这项研究中，我们将研究血流动力学负荷如高血压是否会导致机械敏感通道的功能障碍，并探讨机械传感器在肥厚形成和心力衰竭进展中的作用。心衰加重的分子途径的阐明将使我们能够筛选符合实际临床环境的新型治疗靶点分子和治疗研究对象。

In order to elucidate the in vivo mechanotransduction system, it is essential to conduct molecular cell physiological analysis targeting mechanosensitive channel molecules, as well as physiological assessment using knockout mice. In this study, we will examine whether or not hemodynamic loads such as hypertension can cause such dysfunction of the mechanosensitive channel, and explore the roles of the mechanosensor in relation to the formation of hypertrophy and progression of heart failure. The elucidation of the molecular pathway involved in the exacerbation of heart failure will enable us to sift through novel treatment target molecules and treatment research subjects in line with the actual clinical settings.