Elucidation of Biological Adaptation and Remodeling Mechanisms to Mechanical Stress Based on the Development of Novel Micro-Electro-Mechanical Systems (MEMS) technology

基于新型微机电系统（MEMS）技术的发展阐明机械应力的生物适应和重塑机制

• 批准号: 22240056
• 负责人: NARUSE Keiji
• 金额: $ 32.36万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22240056/
• 关键词: メカノセンサー; 機械受容システム; メカノトランスダクション; Ca2+輸送体; チャネル; 医工学的手法; トランスポーター; 機械受容; 生理機能; チャネル・トランスポーター

Physical and mechanical stimuli such as gravity, extension, and shearing stress are generated throughout a living body. It has been gradually revealed that these stimuli, which are transmitted via the mechanotransduction mechanisms of cells, are not simply detrimental stresses for living organisms, but rather are biological information essential to developmental processes and functional adaptation of organs. In this project, on the basis of the development of original loading systems for mechanical stress to cells and tissues, the cellular adaptive responses to the mechanical stimuli and their transduction mechanisms in a variety of mechanosensitive tissues are to be examined. Thus, the project aims toelucidate the molecular mechanisms and roles of mechanotransduction system, which is utilized as a basis of many physiological events. It can also contribute to develop therapeutic approach to cancer invasion, cardiac hypertrophy, and regeneration of neuronal circuit.

物理和机械刺激，如重力，拉伸和剪切应力，在整个生命体中产生。人们逐渐发现，这些刺激，这是通过细胞的mechanotransductionmechanisms传输，不仅是有害的压力，为活的有机体，而是生物信息的发育过程和器官的功能适应必不可少的。本课题在开发细胞和组织机械应力加载系统的基础上，研究了各种机械敏感组织对机械刺激的适应性反应及其转导机制。因此，该项目旨在阐明机械力传导系统的分子机制和作用，该系统被用作许多生理事件的基础。它还可以有助于开发癌症侵袭、心脏肥大和神经回路再生的治疗方法。

项目成果

Clin Calcium (A novel approach to mechanotransduction using cell-adhesion-patterned cells)

Clin Calcium（使用细胞粘附图案细胞进行机械转导的新方法）

• 发表时间: 2010
• 作者: Yuki Katanosaka;Keiji Naruse
• 通讯作者: Keiji Naruse

血管医学(新しい伸展刺激負荷方法を用いたメカノトランスダクション研究)

血管医学（使用新的拉伸刺激加载方法进行机械传导研究）

• 发表时间: 2010
• 作者: 片野坂友紀;成瀬恵治
• 通讯作者: 成瀬恵治

The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel

• DOI: 10.1016/j.biomaterials.2011.10.049
• 发表时间: 2012-02-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Nagai, Yusuke;Yokoi, Hidenori;Naruse, Keiji
• 通讯作者: Naruse, Keiji

The role of stretch-activated channel on myogenic differentiation of skeletal myoblast

牵张激活通道对骨骼肌成肌细胞生肌分化的作用

• 发表时间: 2010
• 作者: Yuki Katanosaka;Satosh Mohri;Keiji Naruse
• 通讯作者: Keiji Naruse

In-vitro Culture with a Tilting Device in Chemically Defined Media During Meiotic Maturation and Early Development Improves the Quality of Blastocysts Derived from In-vitro Matured and Fertilized Porcine Oocytes

• DOI: 10.1262/jrd.10-041h
• 发表时间: 2010-10-01
• 期刊: JOURNAL OF REPRODUCTION AND DEVELOPMENT
• 影响因子: 1.8
• 作者: Koike, Takayuki;Matsuura, Koji;Funahashi, Hiroaki
• 通讯作者: Funahashi, Hiroaki