Application of Soft Lithography to Mechanobiology

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In this research project, we focused on mechanosensitive mechanism of mammalian from molecular to individual level. We constructed analysis methods of mechanical and medicinal stimuli using softlithography to construct features measured on the micrometer to nanometer scale, and then employed it into stimuli-response analysis. High-speed atomic force microscope was applied to observe molecular dynamics in aqueous environment with high spatiotemporal resolution, and we elucidated molecular dynamics of the mechanosensitive molecules.