Molecular basis of autophagy as a cellular survival strategy

真核细胞通过自噬维持其生命，自噬是一种细胞内多方面的体积降解系统。为了理解自噬是一种细胞生存策略，我们对自噬进行了分子解剖。结果发现，Atg16L复合物将LC3锚定在自噬膜结构上，LC3是完成自噬膜结构所必需的。此外，该结构的形成发生在内质网膜衍生的特殊“摇篮”内。

Eukaryotic cells maintain their life by using autophagy, an intracellular bulk degradation system in the diverse aspects. To understand autophagy as a cellular survival strategy, we achieved molecular dissection of autophagy. In results, we found that Atg16L complex anchors LC3 to the autophagic membrane structure and that LC3 is required for completion of the structure. Furthermore, formation of the structure occurs inside of the special "cradle" derived from the endoplasmic reticulum membranes.