Effects of environmental pollutants on cancer in wildlife

我们调查了环境化学物质在野生动物中的生物累积水平，例如致癌物质和致癌物质，并阐明了这些环境有毒化合物的影响。我们从鸟类和哺乳动物(包括珍稀野生动物)中克隆了细胞色素P450 1亚家族、芳烃受体和II相酶，这些酶有助于激活或解毒致癌物和前致癌物，并对这些分子进行了鉴定。我们还报道了野生动物中这些酶和调节受体的分子进化。

We investigated bioaccumulation levels of environmental chemicals, e.g., carcinogens and pro-carcinogens, in wildlife and elucidated the effects of these environmental toxic compounds. We cloned cytochrome P450 1 subfamilies, arylhydrocarbon receptors and phase II enzymes, which contribute to activation or detoxification of carcinogens and procarcinogens, from bird and mammalian species including rare wildlife, and characterized these molecules. We also reported the molecular evolution of these enzymes and regulation receptors in wildlife.