Clarifying the therapeutic mechanism of psychiatric disorders through the regulation of inflammation in the brain via microglial TRP channels

通过小胶质细胞 TRP 通道调节大脑炎症来阐明精神疾病的治疗机制

• 批准号: 19K20760
• 负责人: sato mina
• 金额: $ 1.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-08-25 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K20760/
• 关键词: ミクログリア; ＴＲＰチャネル; うつ病; 統合失調症; 血液由来ミクログリア様（iMG）細胞; フィンドリモド; アリピプラゾール; 抗精神病薬; TRPM7チャネル; TNF－α; TRPチャネル; 抗うつ薬

项目成果

Modulating microglial activation as a possible therapeutic target for depression. pp 209-219, Understanding Depression - Volume 1. biomedical and Neurobiological Background (Edited by Kim YK)

调节小胶质细胞活化作为抑郁症的可能治疗靶点。

• 发表时间: 2018
• 作者: Sato-Kasai M;Kato TA*;Ohgidani M;Horikawa H;Mizoguchi Y;Monji A;Kanba S
• 通讯作者: Kanba S

Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study

• DOI: 10.1016/j.jad.2018.07.040
• 发表时间: 2018-11-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Kuwano, Nobuki;Kato, Takahiro A.;Kanba, Shigenobu
• 通讯作者: Kanba, Shigenobu

Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.

• DOI: 10.1038/s41598-018-21260-w
• 发表时间: 2018-02-13
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Hayakawa K;Kato TA;Watabe M;Teo AR;Horikawa H;Kuwano N;Shimokawa N;Sato-Kasai M;Kubo H;Ohgidani M;Sagata N;Toda H;Tateno M;Shinfuku N;Kishimoto J;Kanba S
• 通讯作者: Kanba S