Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.
Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.
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DOI：
10.1038/s41598-018-21260-w
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发表时间：
2018-02-13
影响因子：
4.6
通讯作者：
Kanba S
中科院分区：
文献类型：
--
作者：
Hayakawa K;Kato TA;Watabe M;Teo AR;Horikawa H;Kuwano N;Shimokawa N;Sato-Kasai M;Kubo H;Ohgidani M;Sagata N;Toda H;Tateno M;Shinfuku N;Kishimoto J;Kanba S
隐居癖是一种严重的社会退缩综合征，在日本和国际上都是一个日益严重的社会问题。隐蔽青年的病理生理学尚未阐明，有效的治疗方法仍有待建立。最近，我们发现，回避型人格障碍是最常见的并发症的hikikomori。因此，我们假设回避型人格是隐藏青年的人格基础。首先，我们在此显示回避型人格特质，血液生物标志物，hikikomori相关的心理特征，并在非hikikomori志愿者的信任游戏评估的行为特征之间的关系。男性回避型人格特质与高密度脂蛋白胆固醇（HDL-C）和尿酸（UA）呈负相关，女性回避型人格特质与纤维蛋白变性产物（FDP）和高敏C反应蛋白（hsCRP）呈正相关。接下来，我们招募了实际的hikikomori个体，并比较了hikikomori个体和年龄匹配的健康对照者之间的回避型人格特征，血液生物标志物和心理特征。与健康对照组相比，青年隐居症患者的回避型人格得分在男性和女性中均较高，男性的血清UA水平较低，女性的HDL-C水平较低。这是第一份显示hikikomori可能的血液生物标志物的报告，并为阐明hikikomori的潜在生物病理生理学打开了大门。
Hikikomori, a severe form of social withdrawal syndrome, is a growing social issue in Japan and internationally. The pathophysiology of hikikomori has not yet been elucidated and an effective treatment remains to be established. Recently, we revealed that avoidant personality disorder is the most common comorbidity of hikikomori. Thus, we have postulated that avoidant personality is the personality underpinning hikikomori. First, we herein show relationships between avoidant personality traits, blood biomarkers, hikikomori-related psychological features, and behavioural characteristics assessed by a trust game in non-hikikomori volunteers. Avoidant personality traits were negatively associated with high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) in men, and positively associated with fibrin degeneration products (FDP) and high sensitivity C-reactive protein (hsCRP) in women. Next, we recruited actual individuals with hikikomori, and compared avoidant personality traits, blood biomarkers, and psychological features between individuals with hikikomori and age-matched healthy controls. Individuals with hikikomori had higher avoidant personality scores in both sexes, and showed lower serum UA levels in men and lower HDL-C levels in women compared with healthy controls. This is the first report showing possible blood biomarkers for hikikomori, and opens the door to clarify the underlying biological pathophysiology of hikikomori.
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影响因子：
4.7
作者：
Kato TA;Watabe M;Kanba S
通讯作者：
Kanba S
影响因子：
2.9
作者：
Kato TA;Kanba S
通讯作者：
Kanba S
影响因子：
3.7
作者：
Kato TA;Watabe M;Tsuboi S;Ishikawa K;Hashiya K;Monji A;Utsumi H;Kanba S
通讯作者：
Kanba S
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
3.5
作者：
Kato TA;Hayakawa K;Monji A;Kanba S
通讯作者：
Kanba S