Sensor proteins and cellular protection factors for environmental electrophiles

环境亲电体暴露于培养的细胞和实验动物引起传感器蛋白如PTP1B和Keap1的反应性硫醇的共价或氧化修饰，从而分别激活EGFR和Nrf2。我们的研究结果表明，环境亲电物质侵入细胞，然后可以调节细胞信号转导途径（例如，初始反应、细胞增殖和凋亡性细胞死亡）

Exposure of environmental electrophiles to cultured cells and experimental animals caused a covalent or oxidative modification of the reactive thiols of sensor proteins such as PTP1B and Keap1, thereby activating EGFR and Nrf2, respectively. Our findings suggest that environmental electrophiles invade into cells, and then can modulate cellular signal transduction pathways (e.g., initial response, cell proliferation and apoptotic cell death) in a concentration-dependent manner