Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols.
Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols.
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DOI：
10.1016/j.envres.2010.01.009
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发表时间：
2010-04
影响因子：
8.3
通讯作者：
Froines, John R.
中科院分区：
文献类型：
--
作者：
Eiguren-Fernandez, Arantzazu;Shinyashiki, Masaru;Schmitz, Debra A.;DiStefano, Emma;Hinds, William;Kumagai, Yoshito;Cho, Arthur K.;Froines, John R.
颗粒物（PM）一直是旨在了解环境气溶胶的化学性质与不良健康影响之间关系的研究的主要焦点。PM的大小和化学成分与其氧化能力有关，这被认为会促进或加剧肺和心血管疾病。但在过去的几年里，新的研究表明，挥发性和半挥发性成分也可能导致许多不利的健康影响。本研究的目的是：i）首次评估环境气溶胶气相组分的氧化还原和亲电电位，ii）评估颗粒和蒸气组分对给定气溶胶危害的相对贡献。为了实现这些目标，在滨江（CA）收集的气相和颗粒相样品进行了三次化学分析，以确定其氧化还原和亲电能力。结果表明，氧化还原活性组分主要存在于颗粒相中，而亲电化合物主要存在于气相中。气相有机提取物还能够诱导RAW 264.7小鼠巨噬细胞中的应激反应蛋白血红素加氧酶-1（HO-1）。这些结果表明挥发性组分在气溶胶的整体氧化和亲电能力中的重要性，并指出在未来的健康和风险评估研究中需要纳入蒸汽。
Particulate matter (PM) has been the primary focus of studies aiming to understand the relationship between the chemical properties of ambient aerosols and adverse health effects. Size and chemical composition of PM have been linked to their oxidative capacity which has been postulated to promote or exacerbate pulmonary and cardiovascular diseases. But in the last few years, new studies have suggested that volatile and semivolatile components may also contribute to many adverse health effects. The objectives of this study were: i) assess for the first time the redox and electrophilic potential of vapor-phase components of ambient aerosols, and ii) evaluate the relative contributions of particle- and vapor-fractions to the hazard of a given aerosol. To achieve these objectives vapor- and particle-phase samples collected in Riverside (CA) were subjected to three chemical assays to determine their redox and electrophilic capacities. The results indicate that redox active components are mainly associated with the particle-phase, while electrophilic compounds are found primarily in the vapor-phase. Vapor-phase organic extracts were also capable of inducing the stress responding protein, heme-oxygenase-1 (HO-1), in RAW264.7 murine macrophages. These results demonstrate the importance of volatile components in the overall oxidative and electrophilic capacity of aerosols, and point out the need for inclusion of vapors in future health and risk assessment studies.
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超铁颗粒在空气颗粒质量与心血管健康之间关联中的潜在作用。
影响因子：
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