Chemical synthesis of glycans and glycoconjugates for elucidation of their functions in immune and nerve system

新的合成方法已被开发用于聚糖和糖缀合物，并将其应用于合成复杂的生物活性分子，以阐明作用机制。特别是，免疫刺激或免疫调节的糖缀合物从细菌合成的先天免疫受体的识别阐明。天然免疫受体的合成配体用于免疫调节。还研究了聚糖和糖蛋白的生物成像研究，用于聚糖的动态和动力学分析，以揭示聚糖的未知功能。

New synthetic methods have been developed for glycans and glycoconjugates and applied them to the synthesis of complex bioactive molecules for the elucidation of action mechanisms. In particular, immunostimulating or immunomodulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthetic ligands for the innate immune receptors were used for the immune regulation. Bio-imaging studies of glycans and glycoproteins were also studied for the dynamic and kinetic analysis of glycans to unveil the unknown function of glycans.