Functional Funnel of Molecular Motors

蛋白质马达在温和的温度条件下表现出良好的上级工作能力，能够灵活地响应外界的负载。在本研究项目中，从理论上研究了蛋白质机器，以揭示其物理原理：（1）构建粗粒度模型来分析肌球蛋白和其他蛋白质的大结构波动，并建立了理解变构转换的理论框架;（2）模拟了运动蛋白质的毫秒时间尺度轨迹;（3）提出并严格检验了分子马达的功能漏斗假设。

Protein motors show the superior abilities in working efficiently at the mild temperature by responding flexibly to the applied load. In this research project, protein machines were studied theoretically to reveal their physical principles :(1) Coarse-grained models were constructed to analyze the large structural fluctuation of myosins and other proteins, and the theoretical framework to understand allosteric transitions is developed,(2) the millisecond time-scale trajectories of moving proteins were simulated, and(3) the functional funnel hypothesis of molecular motors was proposed and critically examined.