Targeted design of superalloy membranes and their application processes for the production of colloidal, lipid-based drug carrier systems

高温合金膜的针对性设计及其用于生产胶体、脂质药物载体系统的应用工艺

• 批准号: 451891484
• 负责人: Professorin Dr. Heike Bunjes
• 金额: --
• 依托单位: Institut für Pharmazeutische Technologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/451891484?language=en
• 关键词: Targeted; design; superalloy; membranes; their

Superalloy membranes combine good mechanical strength and thermal resistance with very fine pores in the nanometer range. The combination of these properties is not achieved by typical membrane materials such as alumina, glass or polymers. In the field of pharmaceutical nanoemulsification processes, premix membrane emulsification is currently being investigated amongst others, in which the use of membranes with increased mechanical strength and thermal resistance can expand the possibilities of process control and thus open up new application possibilities. In a first joint interdisciplinary study by the applicant institutes, it was shown that creep-deformed nanoporous superalloy membranes are generally well suited for premix membrane emulsification. The project described in the application is intended, on the one hand, to fundamentally investigate and explore the material specific aspects and challenges of membrane fabrication with regard to the application of premix membrane emulsification. Furthermore, the process of premix membrane emulsification with the superalloy membranes shall be investigated in detail. This includes the interactions between the membranes and the pharmaceutical emulsions, the exploration of possible process windows and the procedural characterization of the membranes. The aim of the research is to comprehensively understand the design of the nanoporous superalloy membranes as alternative membrane material and to explore their process application with the help of a suitable model test bench. While the expertise in the field of superalloy membranes is represented at the Institute of Materials, in the fields of process engineering and pharmacy it is contributed by the Institutes of Particle Technology and Pharmaceutical Technology.

超级合金膜联合收割机结合了良好的机械强度和耐热性以及纳米范围内的非常细的孔。这些特性的组合不是通过典型的膜材料如氧化铝、玻璃或聚合物实现的。在药物纳米乳化工艺领域，目前正在研究预混膜乳化等，其中使用具有增加的机械强度和耐热性的膜可以扩大工艺控制的可能性，从而开辟新的应用可能性。在申请机构的第一个联合跨学科研究中，显示蠕变变形的纳米多孔超合金膜通常非常适合于预混膜乳化。申请中描述的项目旨在从根本上研究和探索与预混膜乳化应用有关的膜制造的材料特定方面和挑战。此外，还对高温合金膜预混膜乳化过程进行了详细的研究。这包括膜和药物乳剂之间的相互作用，可能的工艺窗口的探索和膜的程序表征。研究的目的是全面了解纳米多孔高温合金膜作为替代膜材料的设计，并探索其过程中的应用与一个合适的模型试验台的帮助下。虽然材料研究所在高温合金膜领域拥有专业知识，但在工艺工程和制药领域，颗粒技术和制药技术研究所提供了专业知识。