The influence of the anesthetics on cerebral nerve circuit construction in period of growth by visible of the GABAergic neurons

从GABA能神经元可见情况观察麻醉药物对生长期脑神经回路构建的影响

• 批准号: 21890032
• 负责人: KUBO Kazuhiro
• 金额: $ 1.22万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890032/
• 关键词: GFP; GAD67; 吸入麻酔薬

I administered 1.5% sevoflurane for each 12 hours on 1st day, 3rd day and 5th day after birth. After maturity, I examined teachability to go through a hippocampus, a base nucleus, a cerebral cortex, the cerebellum by Morris water maze test. As a result, the teachability of the sevoflurane treated group, the teachability of the sense of position in particular did not have a difference in comparison with the non-anesthesia group either.Next, I examined Elevated plus maze test. As a result, the tendency that an anxiety behavior increased was seen with the sevoflurane treated group.

出生后第1天、第3天、第5天，每隔12小时注射1.5%七氟醚。成熟期后，通过Morris水迷宫实验检测可教性，通过海马体、基底核、大脑皮层、小脑。因此，七氟醚治疗组的可教性，特别是位置感的可教性与非麻醉组相比也没有差异。接下来，我进行了高架加迷宫试验。结果，七氟醚治疗组的焦虑行为有增加的趋势。

项目成果

セボフルラン麻酔からの覚醒への低用量レミフェンタニル持続併用の影響

连续小剂量瑞芬太尼联合用药对七氟醚麻醉苏醒的影响

• 发表时间: 2010
• 作者: 磯辺智範;阿久津博義;椎貝真成;平野雄二;岡本嘉一;山本哲哉;只野喜一;佐藤英介;阿武泉;鈴木由里子;増本智彦;松村明;Kubo K;Ishitobi H;森川泰如;天田早香
• 通讯作者: 天田早香

Altered Responses to Propofol, but Not Ketamine, in Mice Deficient in the 65-Kilodalton Isoform of Glutamate Decarboxylase

• DOI: 10.1124/jpet.109.151456
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Kubo, Kazuhiro;Nishikawa, Koichi;Saito, Shigeru
• 通讯作者: Saito, Shigeru

セボフルラン麻酔からの覚醒への低容量レミフェンタニル持続併用の影響

连续小剂量瑞芬太尼联合用药对七氟醚麻醉苏醒的影响

• 发表时间: 2010
• 作者: Tadano K;Isobe T;Akutsu H;Hirano Y;Shiigai M;Sato E;Nakai K;Yamamoto T;Masumoto T;Matsumura A;伊東史子;森川泰如;天田早香
• 通讯作者: 天田早香

Thermal Hyperalgesia via Supraspinal Mechanisms in Mice Lacking Glutamate Decarboxylase 65

• DOI: 10.1124/jpet.109.156034
• 发表时间: 2009-10-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Kubo, Kazuhiro;Nishikawa, Koichi;Saito, Shigeru
• 通讯作者: Saito, Shigeru