The influence of the anesthetics on cerebral nerve circuit construction in period of growth by visible of the GABAergic neurons

我在出生后第1天、第3天和第5天给予1.5%七氟烷，每12小时一次。成年后，通过Morris水迷宫测试，对海马、基底核、大脑皮质、小脑进行可教性检测。结果，七氟烷治疗组的可教性，特别是位置感的可教性与非麻醉组相比也没有差异。接下来，我检查了高架十字迷宫试验。因此，在七氟烷给药组中观察到焦虑行为增加的趋势。

I administered 1.5% sevoflurane for each 12 hours on 1st day, 3rd day and 5th day after birth. After maturity, I examined teachability to go through a hippocampus, a base nucleus, a cerebral cortex, the cerebellum by Morris water maze test. As a result, the teachability of the sevoflurane treated group, the teachability of the sense of position in particular did not have a difference in comparison with the non-anesthesia group either.Next, I examined Elevated plus maze test. As a result, the tendency that an anxiety behavior increased was seen with the sevoflurane treated group.