Research on the asymmetry of phospholipid bilayer and the oxidation stability

磷脂双层不对称性及氧化稳定性研究

• 批准号: 22580153
• 负责人: KUBO Kazuhiro
• 金额: $ 2.91万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22580153/
• 关键词: 栄養生化学; アシンメトリー; リン脂質; 酸化; ビタミンE; コレステロール

Although the lipid molecular species of inside-and-outside layer in biomembrane phospholipid bilayer differ extremely, influence of the asymmetric distribution for lipid peroxidation in the phospholipid bilayer is disregarded in most of studies. In the present study, it was observed that cholesterol showed the antioxidation ability more than equivalent compared with vitamin E at physiological concentrations, and not only the asymmetry of phospholipid bilayer but also the molecular shape of coexistence phospholipid affected the antioxidation ability of cholesterol. However, the both results of in vitro system and in vivo system were not in agreement.

尽管生物膜磷脂双层内外层的脂类分子种类差异很大，但大多数研究忽略了磷脂双层膜中不对称分布对脂质过氧化的影响。在本研究中发现，在生理浓度下，胆固醇的抗氧化能力强于维生素E，而且不仅磷脂双层的不对称性，而且共存磷脂的分子形态也影响胆固醇的抗氧化能力。然而，体外系统和体内系统的结果并不一致。