Roles of intraoral digestion on regulation of glucose metabolism

口腔内消化对葡萄糖代谢调节的作用

• 批准号: 21890040
• 负责人: KASAMATSU Atsushi
• 金额: $ 1.66万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890040/
• 关键词: 口腔内消化; 糖代謝; 生理学; 糖代謝制御; インスリン分泌; インクレチン分泌

Intraoral digestion triggers various biological responses via taste sensation and/or nutrient absorption at upper intestine. Nevertheless, the effect of sweet sensation on the regulation of glucose metabolism remains unknown. We measured GLP-1 secretion in response to test meal ingestion in Japanese male volunteers. Unexpectedly, GLP-1 secretion occurred synchronously with blood glucose rise and non-nutritive sweetener failed to trigger GLP-1 secretion. Therefore, the early GLP-1 secretion requires the direct stimulation with nutrients in the gut rather than the sweet sensation on the tongue.

口内消化通过味觉和/或上肠的营养吸收触发各种生物反应。然而，甜味对葡萄糖代谢调节的影响仍不清楚。我们测量了日本男性志愿者对试验餐摄入的GLP-1分泌。出乎意料的是，GLP-1分泌与血糖升高同步发生，并且非营养性甜味剂未能触发GLP-1分泌。因此，早期GLP-1的分泌需要肠道中营养物质的直接刺激，而不是舌头上的甜味。