Abnormal connectivity in schizophrenia revealed by multi-modal MRI

多模态 MRI 显示精神分裂症的异常连接

• 批准号: 21890119
• 负责人: MIYATA Jun
• 金额: $ 1.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890119/
• 关键词: 統合失調症; MRI; 拡散テンソル画像; connectivity; tract-based spatial statistics; surface-based analysis

Abnormal connectivity in schizophrenia was investigated by means of the structural MRI and diffusion tensor imaging (DTI). In the analysis of gray matter using structural MRI, the association between cortical thickness and age in healthy people and schizophrenia was revealed. In the DTI analysis for white matter, normal cerebral white matter asymmetry was revealed to be reduced or exaggerated in schizophrenia. This abnormal asymmetry was also revealed to be the neural correlate of certain symptoms of schizophrenia.

应用结构磁共振成像和扩散张量成像（DTI）技术，对精神分裂症患者脑内异常连接进行研究。在使用结构MRI对灰质进行分析时，发现了健康人和精神分裂症患者的皮质厚度与年龄之间的关联。在对白色物质的DTI分析中，正常的大脑白色物质不对称性在精神分裂症中被揭示为减少或夸大。这种异常的不对称性也被揭示为精神分裂症某些症状的神经相关性。

项目成果

統合失調症患者における白質統合性の低下と灰白質体積および厚さとの相関について

精神分裂症患者白质完整性下降与灰质体积和厚度的相关性

• 发表时间: 2011
• 作者: 笹本彰彦;宮田淳;久保田学;川田良作;藤本心祐;田中祐輔;澤本仲克;福山秀直;高橋英彦;村井俊哉
• 通讯作者: 村井俊哉

Abnormal white matter asymmetry in schizophrenia demonstrated by tract-based spatial statistics

基于束的空间统计证实精神分裂症中白质异常不对称

• 发表时间: 2010
• 作者: Takaya T;Ono K;Kawamura T;Takanabe R;Kaichi S;Morimoto T;Wada H;Kita T;Shimatsu A;Hasegawa K.;清水洋祐;宮田淳
• 通讯作者: 宮田淳

Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging

• DOI: 10.1002/hbm.21326
• 发表时间: 2012-07-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Miyata, Jun;Sasamoto, Akihiko;Murai, Toshiya
• 通讯作者: Murai, Toshiya

Age-related cortical thinning in schizophrenia

• DOI: 10.1016/j.schres.2010.10.004
• 发表时间: 2011-01-01
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Kubota, Manabu;Miyata, Jun;Murai, Toshiya
• 通讯作者: Murai, Toshiya