Connectivity analysis for neural basis of decision-making process and symptoms of schizophrenia

决策过程的神经基础和精神分裂症症状的连通性分析

• 批准号: 23791329
• 负责人: MIYATA Jun
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791329/
• 关键词: 統合失調症; connectivity; 意思決定; 拡散テンソル画像; Surface-based approach; トラクトグラフィ; Surface- based approach; Voxel-based morphometry; TBSS; コネクティビティ; 主観的QOL; 構造的connectivity; 視床ー皮質経路; 眼窩前頭皮質

Neural basis of decision-making process and symptoms of schizophrenia was investigated by means of connectivity analysis. First, global association between cortical thinning and white matter integrity reduction was found in Schizophrenia. Next, in the pathway between thalamus and orbitofrontal cortex, which is deeply involved in decision-making, reduced white matter integrity was associated with cortical thinning in schizophrenia. Finally, correlation between regional gray matter reduction and subjective quality of life was revealed in schizophrenia.

通过连通性分析研究了决策过程和精神分裂症症状的神经基础。首先，在精神分裂症中发现皮质变薄和白质完整性降低之间存在整体关联。其次，在丘脑和眶额皮质之间的通路中，该通路与决策密切相关，白质完整性降低与精神分裂症患者的皮质变薄有关。最后，揭示了精神分裂症中局部灰质减少与主观生活质量之间的相关性。

项目成果

The correlational research between deterioration of WM integrity and thickness/volume of GM in schizophrenia subjects

精神分裂症患者WM完整性恶化与GM厚度/体积的相关性研究

• 发表时间: 2011
• 作者: Akihiko Sasamoto;Jun Miyata;et al.
• 通讯作者: et al.

Global association between cortical thinning and white matter integrity reduction in schizophrenia.

• DOI: 10.1093/schbul/sbt030
• 发表时间: 2014-03
• 期刊: Schizophrenia bulletin
• 影响因子: 6.6
• 作者: A. Sasamoto;J. Miyata;M. Kubota;K. Hirao;Ryosaku Kawada;Shinsuke Fujimoto;Yusuke Tanaka;Masaaki Hazama;G. Sugihara;N. Sawamoto;H. Fukuyama;Hidehiko Takahashi;T. Murai

統合失調症における思考の柔軟性ー認知的完結欲求と安静時脳活動の相関

精神分裂症的思维灵活性：认知完成需求与静息大脑活动之间的相关性

• 发表时间: 2014
• 作者: 磯部昌憲;宮田淳;横山如人;森康生;杉原玄一;村井俊哉;高橋英彦
• 通讯作者: 高橋英彦

統合失調症における思考の柔軟性-認知的完結欲求と安静時脳活動の相関

精神分裂症的思维灵活性：认知完成需求与静息大脑活动之间的相关性

• 发表时间: 2014
• 作者: 磯部昌憲;宮田淳;横山如人;森康生;杉原玄一;村井俊哉;高橋英彦
• 通讯作者: 高橋英彦

Regional gray matter reduction correlates with subjective quality of life in schizophrenia.

区域灰质减少与精神分裂症患者的主观生活质量相关。

• DOI: 10.1016/j.jpsychires.2013.01.002
• 发表时间: 2013
• 期刊: Journal of Psychiatric Research
• 影响因子: 4.8
• 作者: Ubukata;S.;Miyata;J.;Yoshizumi;M.;Uwatoko;T.;Hirao;K.;Fujiwara;H.;Kawada;R.;Fujimoto;S.;Tanaka;Y.;Kubota;M.;Sasamoto;A.;Sawamoto;N.;Fukuyama;H.;Takahashi;H.;& Murai;T.
• 通讯作者: T.