Connectivity analysis for neural basis of decision-making process and symptoms of schizophrenia

通过连通性分析，探讨精神分裂症决策过程和症状的神经基础。首先，在精神分裂症患者中发现了皮质变薄和白质完整性降低之间的全球联系。接下来，在丘脑和眼眶前额叶皮质之间的通路中，白质完整性降低与精神分裂症患者的皮质变薄有关，该通路与决策密切相关。最后，揭示了精神分裂症患者局部灰质减少与主观生活质量的相关性。

Neural basis of decision-making process and symptoms of schizophrenia was investigated by means of connectivity analysis. First, global association between cortical thinning and white matter integrity reduction was found in Schizophrenia. Next, in the pathway between thalamus and orbitofrontal cortex, which is deeply involved in decision-making, reduced white matter integrity was associated with cortical thinning in schizophrenia. Finally, correlation between regional gray matter reduction and subjective quality of life was revealed in schizophrenia.