Establishment of mouse model of carcinomatous peritonitis for tailor maid cancer therapy.

肿瘤干细胞标记物CD44在T3/4胃癌组织中的表达，探讨CD44表达与进展期T3/4胃腺癌患者癌性腹膜炎等临床病理因素的关系。本研究未发现肿瘤干细胞标志物CD44的表达与临床病理因素之间的相关性。然而，即使在晚期(T3-4)胃腺癌患者中，CD44阳性组的预后也比CD44阴性组差。这些结果提示CD44，一个可能的肿瘤干细胞标记物，可能参与了肿瘤的进展，尽管确切的机制仍有待阐明。

Cancer stem cell marker CD44 expression in T3/4 gastric cancer.We investigated the correlation between expression of CD44 and clinicopathological factors such as carcinomatous peritonitis in patients with advanced T3/4 gastric adenocarcinoma. Present study did not show any correlation between the expression of CD44, known cancer stem cell marker, and clinicopathological factors. However, even among patients with advanced (T3-4) gastric adenocarcinoma, CD44 positive group showed poorer prognosis than CD44 negative one. These results suggested that CD44, putative cancer stem cell marker, might be involved in tumor progression, although the precise mechanism remains to be elucidated.