Development of custom-made virus therapy for gastric cancer using gene expressing oncolytic virus

不可切除的晚期和复发胃癌的治疗一直不令人满意。人们期待使用溶瘤病毒的新疗法。这些病毒的基因有突变，只在肿瘤细胞中复制，但这些突变的基因有时会破坏它们的溶瘤能力。为了提高他们的溶瘤能力，已经做了各种尝试。在本研究中，我们选择了适合胃癌个体的基因，并构建了表达该基因的病毒来促进肿瘤的溶解。免疫组化研究显示个体胃癌基因表达，并进行治疗实验，观察治疗效果增强。

Therapies for unresectable advanced and recurrent gastric cancer have been unsatisfactory. New therapies using oncolytic viruses have been expected. These viruses have mutations on their genes and only replicate in tumor cells, but these mutated genes sometimes spoil their oncolytic ability. To enhance their oncolysis, various attempts have been done. In this study, we selected appropriate gene for individual gastric cancer and construct virus expressing that gene to enhance oncolysis. Immunohistochemical study revealed gene expression of individual gastric cancer and therapeutic experiments were undergone and enhanced therapeutic effects were observed.