Fundamental research project to elucidate the process in which bone marrow side population (SP) cells differentiate into muscle fibers

肌功能的下降是众所周知的随年龄增长的退行性变化。为了阐明肌肉功能重新激活的机制，我们研究了促进骨髓侧群体细胞分化的特定蛋白质，这些蛋白质影响肌肉发育。骨髓侧群细胞在低血清中培养，加入不同的生长因子组合。转化生长因子-β-1和胰岛素样生长因子-1作为参与肌功能再激活的因子，分别影响分化的早期和后续阶段。

The decrease in myofunction is a well known degenerative change with age. To elucidate the mechanisms of myofunctional reactivation, we investigated specific proteins that promote the differentiation of bone marrow side population cells, which influence muscle development. Bone marrow side population cells were cultivated in low serum media, to which various combinations of growth factors were added. As factors involved in myofunctional reactivation, TGF-β1 and IGF-1 influenced the early and subsequent stages of differentiation, respectively.