roteomic, metagenomic and genome-wide analyses of oral cavity of ovariectomized rats with psychological stress

研究按计划进行，但时间表略有变化。心理应激和卵巢切除大鼠口腔的宏基因组研究和全基因组分析已经完成。蛋白质组学研究已计划在明年进行，并进行了一些额外的实验，以更深入地研究这一问题。一项研究，以确定心理压力/抑郁相关的药物是否影响口腔。结果表明，在三环类抗抑郁药阿米替林全身给药后，大鼠的口腔微生物组发生了显著变化。 研究结果发表在一份国际期刊上。另一项研究是确定心理压力是否会影响大鼠唾液腺的基因表达。全基因组分析的结果显示，心理应激后大鼠下颌下腺的基因表达和细胞及分子通路发生了显著变化。这些研究结果在美国的一次国际会议上作了介绍，目前正在分析宏基因组分析和全基因组分析的结果，并准备将其手稿提交一份国际期刊发表。

The research has progressed as planned but with a slight change in schedule. The metagenomic study and genome-wide analysis of the oral cavity in psychological stress and ovariectomized rats have been completed. The proteomic study has been planned for the coming year.Some additional experiments were performed to investigate the matter deeper. A study to determine if psychological stress/depression-related drugs affect the oral cavity. The results showed that there was a significant alteration in oral microbiome after the tricyclic antidepressant, amitriptyline was systemically administered to rats. The results were published in an international journal.Another study was performed to determine if psychological stress affects the gene expression of salivary glands in rats. The results of the genome-wide analysis showed significant alteration in gene expression and cellular and molecular pathways in the submandibular gland of rats after psychological stress. The findings were presented at an international conference in the United States.The results of metagenomic analyses and genome-wide analysis are being analyzed and the manuscript is being prepared to submit it for publication in an international journal.