The functional elucidation of salivary protein histatin toward the development of anti-inflammatory agent

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Salivary protein histatin has antimicrobial activity toward pathogenic bacteria of periodontitis. However, the effect of histatin on living body (host) is scarcely clarified. In this study, histatin showed the enhancement of human gingival fibroblast (which constitute the major cellular population of gingival tissue) proliferation. It became apparent that histatin is an anti-inflammatory factor. These observations suggest that wound healing induced by inflammatory, etc., in the oral cavity is earlier than that in the other tissues and organs. Moreover, it seems more likely that the salivary protein is developed as an anti-inflammatory agent.