Elucidation of the mechanism of action in salivary protein histatin aimed at soft tissue injury treatment and regenerative medicine

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Salivary protein histatins have antimicrobial properties and protect oral tissues from pathogens (e.g., periodontal pathogens and Candida albicans). However, very little is known about the function of histatins against host cells. In this study, we showed a part of mechanism enhancing cell proliferation by histatin in human gingival fibroblasts. It has also been suggested the possibility that histatin is concerned with other cell cycle regulatory functions. In addition, we showed the mechanism of anti-inflammatory action by histatin. These observations are advocated as new physiological function of salivary protein. These results are connected with regenerative medicine (and tissue engineering) and with development of anti-inflammatory agent.