Elucidation of the mechanism of action in salivary protein histatin aimed at soft tissue injury treatment and regenerative medicine

阐明唾液蛋白组蛋白的作用机制，用于软组织损伤治疗和再生医学

• 批准号: 23592906
• 负责人: IMAMURA Yasuhiro
• 金额: $ 3.33万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592906/
• 关键词: 唾液蛋白質; ヒスタチン

Salivary protein histatins have antimicrobial properties and protect oral tissues from pathogens (e.g., periodontal pathogens and Candida albicans). However, very little is known about the function of histatins against host cells. In this study, we showed a part of mechanism enhancing cell proliferation by histatin in human gingival fibroblasts. It has also been suggested the possibility that histatin is concerned with other cell cycle regulatory functions. In addition, we showed the mechanism of anti-inflammatory action by histatin. These observations are advocated as new physiological function of salivary protein. These results are connected with regenerative medicine (and tissue engineering) and with development of anti-inflammatory agent.

唾液蛋白组胺素具有抗微生物特性并保护口腔组织免受病原体（例如，牙周病原体和白色念珠菌）。然而，很少有人知道组胺素对宿主细胞的功能。在本研究中，我们揭示了组胺素促进人牙龈成纤维细胞增殖的部分机制。也有人认为组胺素可能与其他细胞周期调节功能有关。此外，我们还揭示了组胺素的抗炎作用机制。这些观察结果被认为是唾液蛋白的新生理功能。这些结果与再生医学（和组织工程）和抗炎剂的发展有关。

项目成果

A Novel Single Nucleotide Polymorphism of the Interleukin-8 Promoter: Its Transcriptional Regulation and Analysis of the Mutation in Periodontal Disease in the Japanese Population

• DOI: 10.2485/jhtb.21.427
• 发表时间: 2012
• 期刊: Journal of Hard Tissue Biology
• 影响因子: 0.4
• 作者: Y. Imamura;Yoshihisa Fujigaki;Kouichi Higaki;N. Yoshinari;Pao‐Li Wang

唾液ヒスタチンによる熱ショック蛋白質のTLR2シグナル活性化抑制

唾液组蛋白抑制热休克蛋白TLR2信号激活

• 发表时间: 2011
• 作者: ISHII K;MATSUO M;TAKAHASHI SS;HOSHI N;KIMOTO K;今村泰弘
• 通讯作者: 今村泰弘

Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts.

• DOI: 10.1186/1476-9255-11-4
• 发表时间: 2014-02-04
• 期刊: Journal of inflammation (London, England)
• 作者: Imamura Y;Wang PL
• 通讯作者: Wang PL

唾液ヒスタチンによる熱ショック蛋白質のToll 様受容体リガンド効果抑制機序

唾液组蛋白抑制Toll样受体配体对热休克蛋白作用的机制

• 作者: 今村泰弘;王宝禮
• 通讯作者: 王宝禮

唾液ヒスタチンによる熱ショック蛋白質のToll様受容体リガンド効果抑制機序

唾液组蛋白抑制Toll样受体配体对热休克蛋白作用的机制

• 发表时间: 2013
• 作者: 斉田牧子;星 憲幸，野浪 亨，小田切 憲，桑原淳之，山田重雄，木本克彦;今村泰弘
• 通讯作者: 今村泰弘