Biological significance of the unique fatty acid composition of phosphatidylinositol in the asymmetric division of stem cells.
Biological significance of the unique fatty acid composition of phosphatidylinositol in the asymmetric division of stem cells.
批准号:
22890032
负责人:
IMAE Rieko
金额:
$2.01万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Intracellular phospholipase A1(ipla-1) and acyltransferases(acl-8, acl-9 and acl-10) determine the sn-1 fatty acyl chain of phosphatidylinositol(PI) in C. elegans. In both ipla-1 mutants and acl-8 acl-9 acl-10 triple mutants, the sn-1 fatty acid composition of PI is significantly altered, and asymmetric division of stem cell-like epithelial cells is defective. This study identified the molecules that are associated with the asymmetric division defects caused by the altered fatty acid composition of PI. In addition, functional conservation of acl-8,-9,-10 in mammals was examined.
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Intracellular PLA_1, and acyltransferase, which are involved in C.elegans stem cell divisions, determine the Sn-1 fatty acyl chain of phosphatidylinositol
参与线虫干细胞分裂的细胞内 PLA_1 和酰基转移酶决定磷脂酰肌醇的 Sn-1 脂肪酰基链
DOI:
--
发表时间:
2010
期刊:
Mol.Biol.Cell
影响因子:
--
作者:
[Taichiro Tomida, Mutsuhiro Takekawa, Pauline O'Grady, Haruo Saito, Imae R.]
通讯作者:
Imae R.
DOI:
10.1091/mbc.e10-03-0195
发表时间:
2010-09-15
期刊:
Molecular biology of the cell
影响因子:
3.3
作者:
[Imae R, Inoue T, Kimura M, Kanamori T, Tomioka NH, Kage-Nakadai E, Mitani S, Arai H]
通讯作者:
Arai H
DOI:
10.1194/jlr.m018655
发表时间:
2012-03-01
期刊:
JOURNAL OF LIPID RESEARCH
影响因子:
6.5
作者:
[Imae, Rieko, Inoue, Takao, Arai, Hiroyuki]
通讯作者:
Arai, Hiroyuki
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DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Analysis of the molecular mechanisms involved in the intercellular transfer of double-stranded RNA
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批准号:24790092
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
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财政年份:2012
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负责人:IMAE Rieko
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依托单位:
海外基金