The role of the tryptophan hydroxylase 2 gene in susceptibility to schizophrenia

色氨酸羟化酶2基因在精神分裂症易感性中的作用

• 批准号: 22890065
• 负责人: NUNOKAWA Ayako
• 金额: $ 1.96万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890065/
• 关键词: 統合失調症; リシークエンス; コピー数多様性; タグ一塩基変異; 遺伝子; トリプトファン水酸化酵素

To assess whether the tryptophan hydroxylase 2(TPH2) gene is implicated in vulnerability to schizophrenia, we conducted a two-stage case-control association study in Japanese individuals. In the first stage, we examined a total of 20 markers, including tagging single nucleotide polymorphisms(SNPs), rare missense variations identified through resequencing of protein coding regions, and common copy number variations, in 626 patients and 620 controls. In the second stage, we further investigated potentially associated SNPs in 2007 patients and 2195 controls. However, no evidence was obtained for the associations. Our results suggest that TPH2 does not confer increased susceptibility to schizophrenia in the Japanese population.

为了评估色氨酸羟化酶2（TPH2）基因是否与精神分裂症易感性有关，我们在日本个体中进行了一项两阶段病例对照关联研究。在第一阶段，我们在626名患者和620名对照中共检测了20个标记，包括标记单核苷酸多态性（SNP）、通过蛋白质编码区重测序鉴定的罕见错义变异和常见拷贝数变异。在第二阶段，我们进一步研究了2007例患者和2195例对照中潜在相关的SNP。然而，没有获得任何证据证明这些关联。我们的研究结果表明，TPH2不赋予精神分裂症的易感性增加，在日本人口。

项目成果

Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case–control association study

• DOI: 10.1016/j.schres.2010.01.023
• 发表时间: 2010-05
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: Hideki Amagane;Yuichiro Watanabe;N. Kaneko;A. Nunokawa;T. Muratake;H. Ishiguro;T. Arinami;H. Ujike;T. Inada;N. Iwata;H. Kunugi;Tsukasa Sasaki;R. Hashimoto;M. Itokawa;N. Ozaki;T. Someya

ドパミンD3受容体遺伝子と統合失調症のリスク

多巴胺 D3 受体基因与精神分裂症风险

• 发表时间: 2010
• 作者: 布川綾子;渡部雄一郎;金子尚史;須貝拓朗;矢崎沙織;有波忠雄;氏家寛;稲田俊也;岩田仲生;功刀浩;佐々木司;糸川昌成;尾崎紀夫;橋本亮太;染矢俊幸
• 通讯作者: 染矢俊幸

Acase-control study and meta-analysis of association between acommon copy number variation of the glutathione S-transferase mu 1(GSTM 1)gene and schizophrenia(letter).

谷胱甘肽S-转移酶mu 1(GSTM 1)基因常见拷贝数变异与精神分裂症(letter)关联的病例对照研究和荟萃分析。

• 发表时间: 2010
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: 伊藤美智子;菅波孝祥;中川信貴;田中都;亀井康富;小川佳宏;帯田孝之;渡部雄一郎
• 通讯作者: 渡部雄一郎

A case–control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1 (GSTM1) gene and schizophrenia

• DOI: 10.1016/j.schres.2010.08.001
• 发表时间: 2010-12
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: Yuichiro Watanabe;A. Nunokawa;N. Kaneko;T. Someya

統合失調症多発罹患家系における全ゲノムコピー数多型検索

精神分裂症多发病家族的全基因组拷贝数变异搜索

• 发表时间: 2010
• 作者: 金子尚史;渡部雄一郎;村竹辰之;布川綾子;染矢俊幸
• 通讯作者: 染矢俊幸