The role of HER2 in Rheumatoid Arthritis therapy

HER2 在类风湿关节炎治疗中的作用

• 批准号: 22890076
• 负责人: ANDO Takashi
• 金额: $ 1.96万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890076/
• 关键词: 関節リウマチ; 滑膜; HER2; 関節炎モデルマウス; 抗HER2抗体

Approved by the Ethics Committee in the University of Yamanashi, human synovial membrane was collected as a sample of Rheumatoid Arthritis patient on Total Knee Arthroplasty. Although there is a tendency of high expression of HER2 in rheumatoid arthritis synovial membrane samples, have yet to get a significant difference from control group. After anti-HER2 antibody(trastuzumab) treatment, the effect of suppressing synovial cell proliferation was confirmed by WST assay and the appearance of apoptotic cells were detected by FACS analysis.

经山梨县大学伦理委员会批准，采集类风湿关节炎患者的滑膜作为全膝关节置换术的样本。虽然HER2在类风湿关节炎滑膜标本中有高表达的趋势，但与对照组相比尚未得到显著差异。经抗her2抗体（曲妥珠单抗）治疗后，WST法证实其对滑膜细胞增殖的抑制作用，FACS法检测凋亡细胞的形态。

项目成果

Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-alpha stimulation

小鼠椎间盘中 MCP-1 和 MMP-3 的年龄相关表达与 TWEAK 和 TNF-α 刺激相关

• 发表时间: 2012
• 期刊: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• 作者: Fujita K;Ando T;Ohba T;Wako M;SatoN;Nakamura Y;Ohnuma Y;Hara Y;Kato R;Nakao A;Haro H
• 通讯作者: Haro H

T cell recognition of HLA-A2 restricted tumor antigens is impaired by the oncogene HER2

• DOI: 10.1002/ijc.25613
• 发表时间: 2011-01-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Mimura, Kousaku;Ando, Takashi;Kiessling, Rolf
• 通讯作者: Kiessling, Rolf

HER2/HER3 Signaling Regulates NK Cell-Mediated Cytotoxicity via MHC Class I Chain-Related Molecule A and B Expression in Human Breast Cancer Cell Lines

• DOI: 10.4049/jimmunol.1102237
• 发表时间: 2012-03-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Okita, Riki;Mougiakakos, Dimitrios;Kiessling, Rolf
• 通讯作者: Kiessling, Rolf

HER2-HER3シグナルは乳癌細胞株においてMICA/Bの発現を制御する

HER2-HER3信号调节乳腺癌细胞系中MICA/B的表达

• 发表时间: 2011
• 作者: Mimura K;Ando T;Poschke I;Mougiakakos D;Johansson CC;Ichikawa J;Okita R;Nishimura MI;Handke D;Krug N;Choudhury A;Seliger B;et al.;安藤隆
• 通讯作者: 安藤隆