Ultrasound methods for quantitative imaging of the distribution of magnetic nanoparticles in biological tissue in connection with drug delivery concepts and magnetic hyperthermia for localized tumor treatment
用于定量成像生物组织中磁性纳米粒子分布的超声方法,与局部肿瘤治疗的药物输送概念和磁热热疗法相关
基本信息
- 批准号:452821018
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Nanoparticles are of great interest in medical diagnostics and therapy. Because of the small size of single nanoparticles, the so-called EPR effect (Enhanced Permeability and Retention) can be used which allows, after their administration via blood vessels, a strong penetration from the vessels into biological tissue and an intensive impact on the tissue. This applies in particular to tumor tissue since its vascular pores are often enlarged.Magnetic nanoparticles can be moved, spatially accumulated and heated by magnetic fields, which makes them interesting for tumor therapy. The planned project involves two methods: (a) localized chemotherapy, in which drug-carrying magnetic nanoparticles are locally accumulated in the tumor tissue from outside the body using an electromagnet and can in this way release the drugs in the tumor tissue area. This procedure, which reduces the side effects of conventional chemotherapy, is known as Magnetic Drug Targeting (MDT). In the second method, (b) Magnetic Hyperthermia (MH), the particles are heated using an alternating magnetic field and act thermally on the tissue.In both cases, there is a need to monitor the spatial distribution of the particles in the tissue areas to be treated and to quantitatively determine the particle density. Although Magnetic Resonance Imaging (MRI) and Magnetic Particle Imaging (MPI) are suitable in principle for this, these modalities are complex and difficult to apply in the MDT and MH therapy methods. In contrast, ultrasound is known to be a less complex and easy-to-use modality. However, due to their small sizes, nanoparticles only generate extremely weak backscatter in ultrasound and are not visible in conventional ultrasound images. Therefore, special effects have to be utilized for a sonographic detection and visualization of the nanoparticles.In the "magneto-motive" approach, the nanoparticles are stimulated by alternating magnetic fields to perform periodic movements that are transferred to the surrounding biological tissue, making the particle movements indirectly visible with ultrasound and particle distributions qualitatively displayed. An inverse concept also allows a quantitative determination of the particle density. A second approach takes advantage of the fact that the tissue penetrated by nanoparticles changes the bulk mechanical, e.g., elastic properties. The particle density can thus be visualized and quantified using ultrasound elastography. Based on the encouraging results of our own preliminary work, these procedures are to be further developed and investigated as part of the therapy procedures described. At the same time, the chance is examined to influence the representation and quantifiability of the particles by modifying the nanoparticle synthesis. The investigations shall initially be carried out on phantoms and later in animal experiments.
纳米粒子在医学诊断和治疗中具有重要的应用价值。由于单个纳米颗粒的尺寸小,因此可以使用所谓的EPR效应(增强渗透性和保留率),这使得它们通过血管给药后,从血管强烈渗透到生物组织中,并对组织产生强烈的影响。这尤其适用于肿瘤组织,因为它的血管孔经常扩大。磁性纳米颗粒可以在磁场作用下移动、空间积累和加热,这使得它们对肿瘤治疗很有兴趣。计划中的项目包括两种方法:(a)局部化疗,利用电磁铁将携带药物的磁性纳米颗粒从体外局部积聚在肿瘤组织中,并通过这种方式将药物释放到肿瘤组织区域。这种方法可以减少常规化疗的副作用,被称为磁性药物靶向(MDT)。在第二种方法(b)磁热疗(MH)中,使用交变磁场加热颗粒并对组织产生热作用。在这两种情况下,都需要监测待治疗组织区域中颗粒的空间分布,并定量确定颗粒密度。虽然磁共振成像(MRI)和磁颗粒成像(MPI)原则上适用于此,但这些方式复杂,难以应用于MDT和MH治疗方法。相比之下,超声波被认为是一种不那么复杂和易于使用的方式。然而,由于其体积小,纳米颗粒在超声中只产生极弱的反向散射,在常规超声图像中不可见。因此,必须利用特殊效果对纳米颗粒进行超声检测和可视化。在“磁动机”方法中,纳米粒子在交变磁场的刺激下进行周期性运动,并转移到周围的生物组织中,使粒子运动通过超声波间接可见,并定性地显示粒子分布。一个相反的概念也允许粒子密度的定量测定。第二种方法利用了这样一个事实,即被纳米颗粒穿透的组织改变了整体的机械特性,例如弹性特性。因此,可以使用超声弹性成像来可视化和量化颗粒密度。基于我们自己的初步工作的令人鼓舞的结果,这些程序将进一步发展和调查作为治疗程序的一部分所描述的。同时,通过改变纳米粒子的合成,研究了影响纳米粒子表征和可量化性的机会。调查应首先在幽灵上进行,然后在动物实验中进行。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr.-Ing. Helmut Ermert其他文献
Professor Dr.-Ing. Helmut Ermert的其他文献
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{{ truncateString('Professor Dr.-Ing. Helmut Ermert', 18)}}的其他基金
Ultraschallbildgebung für die präklinische Forschung mit Schwerpunkt auf tomographischen Verfahren, insbesondere zur Tumordiagnostik
用于临床前研究的超声成像,重点是断层扫描程序,特别是肿瘤诊断
- 批准号:
26702148 - 财政年份:2006
- 资助金额:
-- - 项目类别:
Research Units
Entwicklung eines Sensorsystems zur In-Prozess Ermittlung der Werkstückformänderung für wirkmedienbasierte Fertigungsverfahren
开发传感器系统,用于在基于主动介质的制造过程中过程中确定工件形状变化
- 批准号:
5320389 - 财政年份:2001
- 资助金额:
-- - 项目类别:
Priority Programmes
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