Mathematical model for quantitatively analysis the pathophysiological characteristics of mouse photoreceptor cell

我们构建了一种新颖的小鼠光感受器数学模型，以定量描述离子电流动力学的电生理特征以及各种光强度下细胞内离子浓度的变化。新模型可用于解释由于光感受器离子电流编码基因突变而导致的电生理特性的病理生理变化。其结果已在JSMBE、LE、Kinki PS、PSJ等年会上进行了报道。目前，我们已经开发了一个模型来估计光感受器的能量消耗和产生，这与多种视网膜疾病有关。更好地了解能量需求和供应可以为分析新的治疗方法提供有效的工具。

We have constructed a novel mathematical model of the mouse photoreceptor to quantitatively describe the electrophysiological characteristics of ionic current dynamics and the changes in intracellular ion concentrations under a variety of light intensities. The new model can be used to explain the pathophysiological changes in electrophysiological properties due to mutations in the ionic current-encoding genes of photoreceptors. The results have been reported in the annual conferences, including JSMBE, LE, Kinki PS, and PSJ. Currently, we have developed a model to estimate the energy consumption&production of photoreceptors, which are linked to several retinal diseases. A better understanding of energy demand&supply may provide an effective tool for analyzing new therapeutic approaches.