A molecular balancing act: understanding metal ion homeostasis in A. baumannii during infection

分子平衡行为：了解鲍曼不动杆菌感染期间的金属离子稳态

• 批准号: nhmrc : GNT1159752
• 金额: $ 64.25万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-balancing-act-baumannii-infection/1379091
• 关键词: molecular; balancing; act; understanding; metal

Bacteria display significant weakness during changes in the abundance of various heavy metals. To exploit this, the host alters the availability of zinc, copper and iron when the bacteria are detected during infection. This study will characterise these host metal fluxes and bacterium's ability to sense and respond to these changes. This will finally elucidate the important role of host-induced metal stress in bacterial clearance and how bacteria overcome this metal stress on a molecular level.

细菌在各种重金属丰度的变化过程中表现出显着的弱点。为了利用这一点，宿主在感染期间检测到细菌时改变锌、铜和铁的可用性。本研究将探讨这些宿主金属通量以及细菌对这些变化的感知和响应能力。这将最终阐明宿主诱导的金属胁迫在细菌清除中的重要作用，以及细菌如何在分子水平上克服这种金属胁迫。