Elucidating functional involvement of transient receptor potential vanilloid 4 (TRPV4) to trigger swallowing reflex

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The aim of this project was to investigate the involvement of TRPV4 in swallowing reflex. So far, TRPV4 expression observed on nerve fibers of the peripheral swallowing-related regions and afferent neurons located in the nodose-petrosal-jugular ganglionic complex (NPJc). TRPV4 majorly localized on large to medium diameter neurons. Topical application of a chemical agonist for TRPV4, GSK1016790A, in the swallowing-related regions dose-dependently facilitated the triggering of swallowing reflex. Prior topical application of an antagonist for TRPV4 significantly reduced the GSK1016790A-induced swallowing reflex. The data obtained in the last year has been published in "Front. Cell. Neurosci." journal. In the coming fiscal year we will conduct research on the involvement of TRPV4 in water-induced swallowing reflex.