Elucidating functional involvement of transient receptor potential vanilloid 4 (TRPV4) to trigger swallowing reflex

阐明瞬时受体电位香草酸 4 (TRPV4) 触发吞咽反射的功能参与

• 批准号: 22K21027
• 负责人: Roy RitaRani
• 金额: $ 1.83万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-08-31 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K21027/
• 关键词: Swallowing Reflex; TRPV4

The aim of this project was to investigate the involvement of TRPV4 in swallowing reflex. So far, TRPV4 expression observed on nerve fibers of the peripheral swallowing-related regions and afferent neurons located in the nodose-petrosal-jugular ganglionic complex (NPJc). TRPV4 majorly localized on large to medium diameter neurons. Topical application of a chemical agonist for TRPV4, GSK1016790A, in the swallowing-related regions dose-dependently facilitated the triggering of swallowing reflex. Prior topical application of an antagonist for TRPV4 significantly reduced the GSK1016790A-induced swallowing reflex. The data obtained in the last year has been published in "Front. Cell. Neurosci." journal. In the coming fiscal year we will conduct research on the involvement of TRPV4 in water-induced swallowing reflex.

本项目的目的是研究TRPV4在吞咽反射中的作用。到目前为止，TRPV4在周围吞咽相关区域的神经纤维和位于结状-岩-颈神经节复合体(NPJc)的传入神经元上都有表达。TRPV4主要定位于大、中直径神经元。在吞咽相关区域局部应用TRPV4的化学激动剂GSK1016790A，可剂量依赖性地促进吞咽反射的触发。预先局部应用TRPV4拮抗剂可显著降低GSK1016790A诱导的吞咽反射。去年获得的数据已发表在《Front.Cell.Neurosci》上。日记。在下一财年，我们将对TRPV4在水诱导的吞咽反射中的作用进行研究。

项目成果

Involvement of TRPV4 channels expressed in the afferents of superior laryngeal nerve for triggering swallowing reflex

喉上神经传入神经中表达的 TRPV4 通道参与触发吞咽反射

• 发表时间: 2022
• 作者: 安藤 宏;Mohammad Zakir Hossain;Rita Rani Roy;海野 俊平;北川 純一
• 通讯作者: 北川 純一