Anti-Cancer Natural Products: Total Synthesis and Biological Evaluation of Lasonolide A and Analogues

抗癌天然产物：拉索内酯A及其类似物的全合成及生物学评价

• 批准号: DP0556268
• 负责人: A/Prof Mark Coster
• 金额: $ 24.27万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-02-17 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0556268
• 关键词: Anti; Cancer; Natural; Products; Total

One in three men and one in four women in Australia will be diagnosed with cancer before they reach 75. Cancer is a leading cause of death within this country with 28% of deaths each year due to this disease. Although there have been advances in the treatment of various forms of cancer there remains a pressing need for new therapies with improved potency, selectivity and reduced side effects. This project will provide new compounds of potential clinical use in the treatment of cancer, thereby aiding the large population of Australians who will be affected by this disease. Furthermore, the new advanced materials produced by this project will aid in the study of biochemical processes involved in cancer.

在澳大利亚，三分之一的男性和四分之一的女性将在75岁之前被诊断出患有癌症。癌症是该国死亡的主要原因，每年有28%的死亡是由于这种疾病。尽管在治疗各种形式的癌症方面已经取得了进展，但仍然迫切需要具有改善的效力、选择性和减少的副作用的新疗法。该项目将提供在治疗癌症方面具有潜在临床用途的新化合物，从而帮助受这种疾病影响的大量澳大利亚人。此外，该项目生产的新的先进材料将有助于研究癌症中涉及的生化过程。