Design and Development of HIV-1 Integrase Inhibitors Based on a Natural Product Lead

基于天然产品先导物的 HIV-1 整合酶抑制剂的设计和开发

• 批准号: DP0556187
• 负责人: A/Prof Mark Coster
• 金额: $ 19.38万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-02-28 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0556187
• 关键词: Design; Development; HIV; Integrase; Inhibitors

HIV/AIDS is a significant health problem with over 40 million people infected with HIV worldwide. Resistance to current drugs is rising rapidly and new therapeutics are urgently needed. This project will bring together local expertise in organic synthesis and virology in order to develop new and better treatments for HIV/AIDS. Ultimately, Australians with HIV may benefit directly from anti-HIV compounds produced and may also benefit from advances in our understanding of this elusive virus resulting from the project.

艾滋病毒/艾滋病是一个严重的健康问题，全世界有超过 4000 万人感染艾滋病毒。对现有药物的耐药性正在迅速上升，迫切需要新的疗法。该项目将汇集当地有机合成和病毒学方面的专业知识，以开发新的、更好的艾滋病毒/艾滋病治疗方法。最终，感染艾滋病毒的澳大利亚人可能会直接受益于所生产的抗艾滋病毒化合物，也可能受益于我们对该项目产生的这种难以捉摸的病毒的理解的进展。