Environmentally sustainable asymmetric synthesis: design and development of chiral hydrogen bonding organocatalysts

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There is a pressing need for more environmentally sustainable and economically viable methods for asymmetric synthesis. This project aims to design, synthesise and evaluate new organocatalysts based on the principle of hydrogen bonding activation, a common feature of Nature's catalysts, enzymes. These inexpensive, non-toxic, air- and moisture-stable catalysts may prove to be more efficient, selective and have broader applicability than catalysts based on transition metals. The growing Australian pharmaceutical and biotechnology industries will benefit from the development of these new Advanced Materials and the training provided to young scientists in the sought-after fields of asymmetric synthesis and catalysis.