Genome-wide association study for abnormal cranio-facial morphology

颅面部形态异常的全基因组关联研究

• 批准号: 23890011
• 负责人: SAITO Fumio
• 金额: $ 1.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890011/
• 关键词: 歯学; ゲノム; 形態異常

Two loci (1q32.2 and 1p22.3) were likely to be as novel susceptibility regions of mandibular prognathism.PLXNA2 and SSX2IP genes were considered as a genetic candidate.PLXNA2 gene is a gene encoding semaphorin co-receptors, and the relations to bone metabolism are reported in semaphorin 3A.SSX2IP gene is related to a Synovium Sarcoma and the temporomandibular joint that is related to mandibular growth has synovial tissue. We speculate that these genes may be also associated with mandibular prognathism.

两个基因座PLXNA 2基因是一个编码脑信号蛋白共受体的基因，SSX2IP基因与滑膜肉瘤有关，与下颌骨生长有关的颞下颌关节有滑膜肉瘤，组织.我们推测这些基因也可能与下颌骨无颌症有关。

项目成果

Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography

三维显微计算机断层扫描对自发性错牙合短形小鼠颅骨和上颌骨形状差异的形态学评估

• DOI: 10.1111/j.1601-6343.2011.01513.x
• 发表时间: 2011
• 期刊: Orthodontics & Craniofacial Research
• 影响因子: 3.1
• 作者: F Saito;et al.
• 通讯作者: et al.

下顎前突症（mandibular prognathism）のゲノムワイド関連解析

下颌前突的全基因组关联分析

• 发表时间: 2012
• 作者: Kuroshima T ;Aoyagi M ;Yasuda M ;Kitamura T,他6名;生野啓一郎
• 通讯作者: 生野啓一郎

Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion

BALB/c-bm/bm自发性错牙合小鼠鼻中隔软骨的组织学研究

• DOI: 10.1111/j.1601-6343.2011.01538.x
• 发表时间: 2012
• 期刊: Orthodontics & craniofacial research
• 影响因子: 3.1
• 作者: Takahashi K;Kajii TS;Tsukamoto Y;Saito F;Wada S;Sugawara-Kato Y;Iida J.
• 通讯作者: Iida J.

下顎前突症(mandibular prognathism)のゲノムワイド 関連解析

下颌前突的全基因组关联分析

• 发表时间: 2012
• 作者: 生野啓一郎;梶井貴史;岡晃;斉藤文男;猪子英俊;石川博之;飯田順一郎
• 通讯作者: 飯田順一郎