Analysis of intracellular trafficking of membrane proteins of Nipah virus

尼帕病毒膜蛋白的细胞内运输分析

• 批准号: 23890038
• 负责人: FUJIYUKI Tomoko
• 金额: $ 2.08万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890038/
• 关键词: ニパウイルス; 膜タンパク質; 細胞内局在; 糖タンパク質; 細胞内輸送; 輸送

To understand intracellular trafficking of membrane glycoprotein (G) of nipah virus, intracellular localization of G expressed in cultured cells was analyzed. G localized in endoplasmic reticulum (ER) and golgi apparatus, suggesting that G is transported through the regular intracellular trafficking pathway of membrane proteins of the hosts. Deletion mutant analysis further suggested that outer membrane region contributes to the transport of G from ER to golgi apparatus. These findings are important clues to understand the intracellular trafficking of the nipah virusmembrane protein.

为了了解尼帕病毒膜糖蛋白(G)在细胞内的转运，分析了在培养细胞中表达的G在细胞内的定位。G定位于内质网(ER)和高尔基体，提示G是通过寄主细胞膜蛋白的常规细胞内转运途径运输的。缺失突变分析进一步表明，外膜区参与了G从内质网到高尔基体的转运。这些发现是了解尼帕病毒膜蛋白在细胞内运输的重要线索。

项目成果

Evidence of a novel immune responsive protein in the Hymenoptera

• DOI: 10.1016/j.ibmb.2011.09.006
• 发表时间: 2011-12-01
• 期刊: INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
• 影响因子: 3.8
• 作者: Albert, Stefan;Gaetschenberger, Heike;Mueller, Martin J.
• 通讯作者: Mueller, Martin J.

Discriminative survey of distribution of Kakugo virus and deformed wing virus in honeybee (Apis mellifera carnica) colonies in Germany

德国蜜蜂 (Apis mellifera carnica) 群体中 Kakugo 病毒和变形翅病毒分布的判别性调查

• 发表时间: 2011
• 作者: Fujiyuki T;Beier H;Azzami K;Tautz J;Kubo T
• 通讯作者: Kubo T

日本の野鳥由来高病原性鳥インフルエンザウイルスの霊長類への感染

灵长类动物感染源自日本野鸟的高致病性禽流感病毒

• 发表时间: 2012
• 作者: 藤幸知子;米田美佐子;安井文彦;倉石武;服部正策;権賢貞;宗片圭祐;木曽有里;喜田宏;小原道法;甲斐知恵子
• 通讯作者: 甲斐知恵子

Evaluation of innate immune stimulating activity of polysaccharides using a silkworm (Bombyx mori) muscle contraction assay

• DOI: 10.5582/ddt.2012.v6.2.88
• 发表时间: 2012-04-01
• 期刊: DRUG DISCOVERIES AND THERAPEUTICS
• 影响因子: 3.1
• 作者: Fujiyuki, Tomoko;Hamamoto, Hiroshi;Sekimizu, Kazuhisa
• 通讯作者: Sekimizu, Kazuhisa