Analysis of intracellular trafficking of membrane proteins of Nipah virus

为了解尼帕病毒膜糖蛋白(G)在细胞内的转运情况，分析了培养细胞中表达的G在细胞内的定位。G定位于内质网（ER）和高尔基体，表明G是通过宿主膜蛋白的细胞内运输途径进行运输的。缺失突变体分析进一步表明，外膜区域参与了G从内质网到高尔基体的运输。这些发现是了解尼帕病毒膜蛋白细胞内转运的重要线索。

To understand intracellular trafficking of membrane glycoprotein (G) of nipah virus, intracellular localization of G expressed in cultured cells was analyzed. G localized in endoplasmic reticulum (ER) and golgi apparatus, suggesting that G is transported through the regular intracellular trafficking pathway of membrane proteins of the hosts. Deletion mutant analysis further suggested that outer membrane region contributes to the transport of G from ER to golgi apparatus. These findings are important clues to understand the intracellular trafficking of the nipah virusmembrane protein.