Gene interaction of morphogenesis for gutter-shaped root

本研究的目的是利用C57L/J品系小鼠(LJ小鼠)和C57BL/6J品系小鼠(B6小鼠)鉴定影响牙根形态的基因。用免疫组织化学方法分析Sonic Hedgehog(SHH)和GLI-Kruppel家族成员GLI1(Gli1)在出生后第10、11、12天的表达模式，发现Hh和Gli1在LJ和B6小鼠牙根分叉区的表达模式不同。提示SHH信号通路参与了C57L/J系小鼠牙根的形成。

The aim of this study was to identify the gene for influencing to tooth root form using C57L/J strain mice(LJ mice) and C57BL/6J strain mice(B6 mice). We performed immunohistochemistry(IHC) to analyze the expression patterns of sonic hedgehog(SHH) and GLI-Kruppel family member GLI1(Gli1) in postnatal days 10, 11, 12.Expression patterns of SHH and Gli1 showed differences in tooth root bifurcation area between LJ mice and B6 mice. It is suggested that SHH signaling pathway is involved to tooth root formation in C57L/J strain mice.