Gene interaction of morphogenesis for gutter-shaped root

沟状根形态发生的基因相互作用

• 批准号: 23890222
• 负责人: TASHIMA Itaru
• 金额: $ 0.92万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890222/
• 关键词: 免疫染色; 樋状根; SHH signaling pathway; C57L/J

The aim of this study was to identify the gene for influencing to tooth root form using C57L/J strain mice(LJ mice) and C57BL/6J strain mice(B6 mice). We performed immunohistochemistry(IHC) to analyze the expression patterns of sonic hedgehog(SHH) and GLI-Kruppel family member GLI1(Gli1) in postnatal days 10, 11, 12.Expression patterns of SHH and Gli1 showed differences in tooth root bifurcation area between LJ mice and B6 mice. It is suggested that SHH signaling pathway is involved to tooth root formation in C57L/J strain mice.

本研究以C57 L/J系小鼠（LJ小鼠）和C57 BL/6 J系小鼠（B6小鼠）为研究对象，对影响牙根形态的基因进行了鉴定。采用免疫组织化学方法检测出生后10、11、12 d小鼠牙根分叉区音刺猬蛋白（SHH）和GLI-Kruppel家族成员GLI 1（Gli 1）的表达。提示SHH信号通路参与了C57 L/J小鼠牙根的形成。