Molecular Characterisation of Metal Transport Proteins

金属转运蛋白的分子表征

• 批准号: DP0556854
• 负责人: Prof Anthony Wedd
• 金额: $ 50.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0556854
• 关键词: Molecular; Characterisation; Metal; Transport; Proteins

The trace metals are essential to life. The secrets of their catalytic and structural roles are under intensive scrutiny. The molecular mechanisms which regulate concentrations of nutrient metals in biological cells remain poorly understood. Errors in metal metabolism cause disease. For example, defects in copper metabolism cause Menkes and Wilson diseases in humans and there are connections of copper and zinc to neuro-degenerative diseases such as Alzheimer and Creutzfeldt-Jakob (mad cow). This project will study the chemistry of metabolic pathways responsible for import of nutrient copper and other metals into biological cells.

痕量金属是生命所必需的。它们的催化和结构作用的秘密正受到密切关注。调节生物细胞中营养金属浓度的分子机制仍然知之甚少。金属代谢的错误会导致疾病。例如，铜代谢缺陷会导致人类患门克斯和威尔逊病，铜和锌与阿尔茨海默病和克雅氏病(疯牛病)等神经退行性疾病有联系。这个项目将研究代谢途径的化学，这些代谢途径负责将营养铜和其他金属输入生物细胞。