Chemistry of the Transport of Nutrient Copper in Biological Cells

生物细胞中营养铜运输的化学

• 批准号: DP1093345
• 负责人: Prof Anthony Wedd
• 金额: $ 34.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093345
• 关键词: Chemistry; Transport; Nutrient; Copper; Biological

Nutrient trace metals such as copper are needed for enzymes by living organisms but are toxic in excess. Defects in copper metabolism cause Menkes and Wilson diseases in humans and there are direct connections to neurodegenerative diseases (eg, Alzheimer, Parkinson, Creutzfeldt-Jakob, motor neuron diseases). It is crucial to understand how healthy cells control toxic but essential copper so that enlightened intervention is possible when disturbances of copper metabolism become pathological. The chemistry of key molecules will be studied to reveal their essential properties and thereby to understand the molecular basis of the copper-linked diseases.

微量营养金属如铜是生物体酶所需的，但过量则有毒。铜代谢缺陷导致人类门克斯和威尔逊病，并与神经退行性疾病（如阿尔茨海默病、帕金森病、克雅氏病、运动神经元疾病）有直接联系。了解健康细胞如何控制有毒但必需的铜是至关重要的，以便在铜代谢紊乱成为病理性时进行开明的干预是可能的。 将研究关键分子的化学，以揭示其基本特性，从而了解铜相关疾病的分子基础。