Molecular Probes for Bio-Metals

生物金属分子探针

• 批准号: DP0877156
• 负责人: Prof Anthony Wedd
• 金额: $ 27.07万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877156
• 关键词: Molecular; Probes; Bio; Metals

The nutrient trace metals are essential to life. Problems with the metabolism of iron, copper and zinc are associated with neuro-degenerative diseases such as Alzheimer's, Parkinson's and CJD (Creutzfeldt-Jakob disease). This proposal will develop molecular probes for detection of iron, zinc, copper, manganese and nickel within biological cells. The work will allow examination of the molecular roles of these bio-metals in unprecedented detail and lead to a better understanding of their roles in normal metabolism and in disease.

微量元素是生命所必需的营养物质。铁、铜和锌的代谢问题与神经退行性疾病如阿尔茨海默氏症、帕金森氏症和克雅氏病（Creutzfeldt-Jakob病）有关。该提案将开发用于检测生物细胞内铁、锌、铜、锰和镍的分子探针。 这项工作将允许以前所未有的细节检查这些生物金属的分子作用，并更好地了解它们在正常代谢和疾病中的作用。