Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies

使用液体微射流和离子成像技术研究溶剂化生物相关分子的能量和动力学

• 批准号: DP0557546
• 负责人: Dr Jason Gascooke
• 金额: $ 29.72万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557546
• 关键词: Energetics; dynamics; solvated; biologically; relevant

The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed us about the strength of the bonds, others have told us where the bonds occur. This project will provide both pieces of information for the first time, allowing us to better understand, and therefore control, biological function. This work will assist in the development of new biotechnology processes, especially in the emerging area of proteomics.

溶液中许多生物分子的形状在决定其生物活性和功能方面起着关键作用。 已知生物分子和水溶剂之间形成的键控制这种形状。 然而，人们对生物分子周围不同位点上这些键的强度和结构知之甚少。 许多实验告诉我们键的强度，其他人告诉我们键在哪里发生。 该项目将首次提供这两种信息，使我们能够更好地了解并控制生物功能。 这项工作将有助于开发新的生物技术过程，特别是在蛋白质组学这一新兴领域。